Different response of rat Kupffer cells to lipopolysaccharide after exposure to T-helper cytokines

Kazuhiro Atsukawa, Hidetsugu Saito, Masahiko Takahashi, Yasutada Akiba, Tazuko Ohishi, Hirotoshi Ebinuma, Iwao Kurose, Hiromasa Ishii

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


Effects of interleukin-4 (IL-4) and interferon-γ (IFN-γ) on rat Kupffer cell (KC) functions were investigated. Lipopolysaccharide (LPS)-stimulated KCs pretreated with IL-4 produced much more prostaglandin E2 than those pretreated with IFN-γ. In contrast, LPS-stimulated KCs pretreated with IFN-γ produced much more tumor necrosis factor-α, and nitrate and nitrite than those pretreated with IL-4. Different morphologic changes were induced after the culture with each cytokine; transformation of KCs into multinucleated giant cells with IL-4 was especially noted. These results suggest that IFN-γ and IL-4, produced by different subsets of T-helper lymphocytes, differently induce KC into specific morphology, and change KC response to endotoxins, possibly resulting in a modulation of hepatic inflammation.

Original languageEnglish
Pages (from-to)332-338
Number of pages7
JournalInternational Hepatology Communications
Issue number6
Publication statusPublished - 1997 Mar
Externally publishedYes


  • interferon-γ
  • interleukin-4
  • nitric oxide
  • prostaglandin E
  • tumor necrosis factor-α

ASJC Scopus subject areas

  • Hepatology


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