TY - JOUR
T1 - Differential gene expression of vascular natriuretic peptide receptor subtype in artery and vein
AU - Yoshimoto, Takanobu
AU - Naruse, Mitsuhide
AU - Naruse, Kiyoko
AU - Shionoya, Kiseko
AU - Tanabe, Akiyo
AU - Tanaka, Masami
AU - Hagiwara, Hiromi
AU - Hirose, Shigehisa
AU - Muraki, Takamura
AU - Demura, Hiroshi
PY - 1995/1/1
Y1 - 1995/1/1
N2 - Although the vasorelaxation by natriuretic peptide (NP) is much less potent in the vein than in the artery, mechanism underlying the phenomenon remains unknown. Since NP receptor consists of three subtypes with different functions, we determined the mRNA level of each NP receptor subtype in the artery and vein by ribonuclease protection assay. In the aorta, NP-A receptor related to the biological action of NP was the predominant form. By contrast, NP-C receptor related mainly to the clearance of NP was the predominant form in the inferior vena cava: NP-C mRNA level was about two fold higher than in the aorta, while both NP-A and NP-B receptor mRNA levels were about half of that in the aorta. These results provide the molecular basis for the different biological response to NP in the artery and vein. Differential gene expression of NP receptor subtype could be an important determinant of the biological actions of NP.
AB - Although the vasorelaxation by natriuretic peptide (NP) is much less potent in the vein than in the artery, mechanism underlying the phenomenon remains unknown. Since NP receptor consists of three subtypes with different functions, we determined the mRNA level of each NP receptor subtype in the artery and vein by ribonuclease protection assay. In the aorta, NP-A receptor related to the biological action of NP was the predominant form. By contrast, NP-C receptor related mainly to the clearance of NP was the predominant form in the inferior vena cava: NP-C mRNA level was about two fold higher than in the aorta, while both NP-A and NP-B receptor mRNA levels were about half of that in the aorta. These results provide the molecular basis for the different biological response to NP in the artery and vein. Differential gene expression of NP receptor subtype could be an important determinant of the biological actions of NP.
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U2 - 10.1006/bbrc.1995.2655
DO - 10.1006/bbrc.1995.2655
M3 - Article
C2 - 7488144
AN - SCOPUS:0028784780
SN - 0006-291X
VL - 216
SP - 535
EP - 539
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
IS - 2
ER -