Differential gene expression of vascular natriuretic peptide receptor subtype in artery and vein

Takanobu Yoshimoto, Mitsuhide Naruse, Kiyoko Naruse, Kiseko Shionoya, Akiyo Tanabe, Masami Tanaka, Hiromi Hagiwara, Shigehisa Hirose, Takamura Muraki, Hiroshi Demura

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Although the vasorelaxation by natriuretic peptide (NP) is much less potent in the vein than in the artery, mechanism underlying the phenomenon remains unknown. Since NP receptor consists of three subtypes with different functions, we determined the mRNA level of each NP receptor subtype in the artery and vein by ribonuclease protection assay. In the aorta, NP-A receptor related to the biological action of NP was the predominant form. By contrast, NP-C receptor related mainly to the clearance of NP was the predominant form in the inferior vena cava: NP-C mRNA level was about two fold higher than in the aorta, while both NP-A and NP-B receptor mRNA levels were about half of that in the aorta. These results provide the molecular basis for the different biological response to NP in the artery and vein. Differential gene expression of NP receptor subtype could be an important determinant of the biological actions of NP.

Original languageEnglish
Pages (from-to)535-539
Number of pages5
JournalBiochemical and Biophysical Research Communications
Issue number2
Publication statusPublished - 1995 Jan 1

ASJC Scopus subject areas

  • Biophysics
  • Biochemistry
  • Molecular Biology
  • Cell Biology


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