@inproceedings{c97fe81e27aa4744a00047c368e6d545,
title = "Differentiation induction of neuronal stem cells in 3D fiber-shaped microenvironment",
abstract = "This paper describes differentiation induction of mouse neuronal stem cells (NSCs) in a fiber-shaped three-dimensional (3D) microenvironment created in a core-shell hydrogel micrfiber. NSCs were encapsulated in the hydrogel fiber and induced differentiation by controlling growth factors in a medium. We successfully demonstrated the differentiation of NSCs to neurons and glial cells in the fiber-shaped 3D microenvironment. Interestingly, we found that the spatial configuration of the differentiated neurons is not uniform: neurons were clustered and localized at the surface of the fibers. These results would significantly advance the applicability of fiber-shaped neuronal tissues to medical transplantation, and at the same time, would provide a confined 3D microenvironment as a tool for stem cell biology.",
keywords = "Coaxial laminar flow, Differentiation, Hydrogel microfiber, Microenvironment, Neuronal stem cells",
author = "H. Onoe and M. Kato-Negishi and S. Takeuchi",
year = "2011",
month = dec,
day = "1",
language = "English",
isbn = "9781618395955",
series = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
pages = "1490--1492",
booktitle = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011",
note = "15th International Conference on Miniaturized Systems for Chemistry and Life Sciences 2011, MicroTAS 2011 ; Conference date: 02-10-2011 Through 06-10-2011",
}