Differing impact of phosphoglycerate mutase 1-deficiency on brown and white adipose tissue

Yohko Yoshida, Ippei Shimizu, Yung Ting Hsiao, Masayoshi Suda, Goro Katsuumi, Masahide Seki, Yutaka Suzuki, Shujiro Okuda, Tomoyoshi Soga, Tohru Minamino

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Brown adipose tissue (BAT) is a metabolically active organ that contributes to the thermogenic response to cold exposure. In addition, other thermogenic cells termed beige adipocytes are generated in white adipose tissue (WAT) by cold exposure. Although activation of brown/beige adipose tissue is associated with mobilization of both glucose and lipids, few studies have focused on the role of glycolytic enzymes in regulating adipose tissue function. We generated mouse models with specific deletion of the glycolytic enzyme phosphoglycerate mutase 1 (PGAM1) from adipose tissue. Deletion of Pgam1 from both BAT and WAT promoted whitening of BAT with beiging of visceral WAT, whereas deletion of Pgam1 from BAT alone led to whitening of BAT without beiging of WAT. Our results demonstrate a potential role of glycolytic enzymes in beiging of visceral WAT and suggest that PGAM1 would be a novel therapeutic target in obesity and diabetes.

Original languageEnglish
Article number104268
JournaliScience
Volume25
Issue number5
DOIs
Publication statusPublished - 2022 May 20

Keywords

  • Molecular biology
  • Molecular physiology
  • Physiology

ASJC Scopus subject areas

  • General

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