Diffuse alveolar hemorrhage associated with dilated cardiomyopathy and sleep apnea syndrome

Ryohei Suematsu; Jun Miyata; Tomoya Sano; Chie Watanabe; Yohei Maki; Yoshifumi Kimizuka; Nobuyoshi Hayashi; Yuji Fujikura; Hiroaki Sugiura; Hiroshi Shinmoto; Akira Taruoka; Yuji Nagatomo; Takeshi Adachi; Akihiko Kawana

doi:10.2169/internalmedicine.5219-20

Diffuse alveolar hemorrhage associated with dilated cardiomyopathy and sleep apnea syndrome

Ryohei Suematsu, Jun Miyata, Tomoya Sano, Chie Watanabe, Yohei Maki, Yoshifumi Kimizuka, Nobuyoshi Hayashi, Yuji Fujikura, Hiroaki Sugiura, Hiroshi Shinmoto, Akira Taruoka, Yuji Nagatomo, Takeshi Adachi, Akihiko Kawana

Research output: Contribution to journal › Article › peer-review

Abstract

We herein report a case of diffuse alveolar hemorrhage (DAH) associated with dilated cardiomyopathy (DCM) and sleep apnea syndrome (SAS) in a 47-year-old man. The patient exhibited recurring dyspnea and bloody sputum. Chest radiography showed bilateral diffuse infiltrative opacities without pleural effusion. A bronchoscopic analysis of bronchoalveolar lavage fluid revealed hemosiderin-laden macrophages. Based on these findings, he was diagnosed with DAH. Laboratory and pathological findings ruled out the possibility of collagen diseases and vasculitis. Overnight polysomnography revealed concomitant severe obstructive SAS. Treatment with continuous positive-pressure ventilation and pharmacological therapy for DCM prevented recurrence of DAH.

Original language	English
Pages (from-to)	1911-1914
Number of pages	4
Journal	Internal Medicine
Volume	60
Issue number	12
DOIs	https://doi.org/10.2169/internalmedicine.5219-20
Publication status	Published - 2021
Externally published	Yes

Keywords

Anemia
Diffuse alveolar hemorrhage
Dilated cardiomyopathy
Negative pressure pulmonary hemorrhage
Sleep apnea syndrome

ASJC Scopus subject areas

Internal Medicine

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10.2169/internalmedicine.5219-20

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title = "Diffuse alveolar hemorrhage associated with dilated cardiomyopathy and sleep apnea syndrome",

abstract = "We herein report a case of diffuse alveolar hemorrhage (DAH) associated with dilated cardiomyopathy (DCM) and sleep apnea syndrome (SAS) in a 47-year-old man. The patient exhibited recurring dyspnea and bloody sputum. Chest radiography showed bilateral diffuse infiltrative opacities without pleural effusion. A bronchoscopic analysis of bronchoalveolar lavage fluid revealed hemosiderin-laden macrophages. Based on these findings, he was diagnosed with DAH. Laboratory and pathological findings ruled out the possibility of collagen diseases and vasculitis. Overnight polysomnography revealed concomitant severe obstructive SAS. Treatment with continuous positive-pressure ventilation and pharmacological therapy for DCM prevented recurrence of DAH.",

keywords = "Anemia, Diffuse alveolar hemorrhage, Dilated cardiomyopathy, Negative pressure pulmonary hemorrhage, Sleep apnea syndrome",

author = "Ryohei Suematsu and Jun Miyata and Tomoya Sano and Chie Watanabe and Yohei Maki and Yoshifumi Kimizuka and Nobuyoshi Hayashi and Yuji Fujikura and Hiroaki Sugiura and Hiroshi Shinmoto and Akira Taruoka and Yuji Nagatomo and Takeshi Adachi and Akihiko Kawana",

note = "Publisher Copyright: {\textcopyright} 2021 The Japanese Society of Internal Medicine.",

year = "2021",

doi = "10.2169/internalmedicine.5219-20",

language = "English",

volume = "60",

pages = "1911--1914",

journal = "Internal Medicine",

issn = "0918-2918",

publisher = "Japanese Society of Internal Medicine",

number = "12",

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TY - JOUR

T1 - Diffuse alveolar hemorrhage associated with dilated cardiomyopathy and sleep apnea syndrome

AU - Suematsu, Ryohei

AU - Miyata, Jun

AU - Sano, Tomoya

AU - Watanabe, Chie

AU - Maki, Yohei

AU - Kimizuka, Yoshifumi

AU - Hayashi, Nobuyoshi

AU - Fujikura, Yuji

AU - Sugiura, Hiroaki

AU - Shinmoto, Hiroshi

AU - Taruoka, Akira

AU - Nagatomo, Yuji

AU - Adachi, Takeshi

AU - Kawana, Akihiko

PY - 2021

Y1 - 2021

N2 - We herein report a case of diffuse alveolar hemorrhage (DAH) associated with dilated cardiomyopathy (DCM) and sleep apnea syndrome (SAS) in a 47-year-old man. The patient exhibited recurring dyspnea and bloody sputum. Chest radiography showed bilateral diffuse infiltrative opacities without pleural effusion. A bronchoscopic analysis of bronchoalveolar lavage fluid revealed hemosiderin-laden macrophages. Based on these findings, he was diagnosed with DAH. Laboratory and pathological findings ruled out the possibility of collagen diseases and vasculitis. Overnight polysomnography revealed concomitant severe obstructive SAS. Treatment with continuous positive-pressure ventilation and pharmacological therapy for DCM prevented recurrence of DAH.

AB - We herein report a case of diffuse alveolar hemorrhage (DAH) associated with dilated cardiomyopathy (DCM) and sleep apnea syndrome (SAS) in a 47-year-old man. The patient exhibited recurring dyspnea and bloody sputum. Chest radiography showed bilateral diffuse infiltrative opacities without pleural effusion. A bronchoscopic analysis of bronchoalveolar lavage fluid revealed hemosiderin-laden macrophages. Based on these findings, he was diagnosed with DAH. Laboratory and pathological findings ruled out the possibility of collagen diseases and vasculitis. Overnight polysomnography revealed concomitant severe obstructive SAS. Treatment with continuous positive-pressure ventilation and pharmacological therapy for DCM prevented recurrence of DAH.

KW - Anemia

KW - Diffuse alveolar hemorrhage

KW - Dilated cardiomyopathy

KW - Negative pressure pulmonary hemorrhage

KW - Sleep apnea syndrome

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U2 - 10.2169/internalmedicine.5219-20

DO - 10.2169/internalmedicine.5219-20

M3 - Article

C2 - 33518557

AN - SCOPUS:85108386428

SN - 0918-2918

VL - 60

SP - 1911

EP - 1914

JO - Internal Medicine

JF - Internal Medicine

IS - 12

ER -

Diffuse alveolar hemorrhage associated with dilated cardiomyopathy and sleep apnea syndrome

Abstract

Keywords

ASJC Scopus subject areas

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