Diffusion kurtosis imaging study of prostate cancer: Preliminary findings

Chiharu Tamura, Hiroshi Shinmoto, Shigeyoshi Soga, Teppei Okamura, Hiroki Sato, Tomoyuki Okuaki, Yuxi Pang, Shigeru Kosuda, Tatsumi Kaji

Research output: Contribution to journalArticlepeer-review

98 Citations (Scopus)


Purpose To evaluate the differences in parameters of diffusion kurtosis imaging (DKI) between prostate cancer, benign prostatic hyperplasia (BPH), and benign peripheral zone (PZ). Materials and Methods Twenty-four foci of prostate cancer, 41 BPH nodules (14 stromal and 27 nonstromal hyperplasia), and 20 benign PZ from 20 patients who underwent radical prostatectomy were investigated. Diffusion-weighted imaging (DWI) was performed using 11 b-values (0-1500 s/mm2). DKI model relates DWI signal decay to parameters that reflect non-Gaussian diffusion coefficient (D) and deviations from normal distribution (K). A mixed model analysis of variance and receiver operating characteristic (ROC) analyses were performed to assess the statistical significance of the metrics of DKI and apparent diffusion coefficient (ADC). Results K was significantly higher in prostate cancer and stromal BPH than in benign PZ (1.19 ± 0.24 and 0.99 ± 0.28 versus 0.63 ± 0.23, P < 0.001 and P < 0.001, respectively). K showed a trend toward higher levels in prostate cancer than in stromal BPH (1.19 ± 0.24 versus 0.99 ± 0.28, P = 0.051). On the ROC analyses, a significant difference in area under the curve was not observed between K and ADC, however, K showed the highest sensitivity among three parameters. Conclusion DKI may contribute to the imaging diagnosis of prostate cancer, especially in the differential diagnosis of prostate cancer and BPH.

Original languageEnglish
Pages (from-to)723-729
Number of pages7
JournalJournal of Magnetic Resonance Imaging
Issue number3
Publication statusPublished - 2014 Sept
Externally publishedYes


  • benign prostatic hyperplasia
  • diffusion
  • kurtosis
  • magnetic resonance imaging
  • prostate cancer

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging


Dive into the research topics of 'Diffusion kurtosis imaging study of prostate cancer: Preliminary findings'. Together they form a unique fingerprint.

Cite this