TY - JOUR
T1 - Diffusion tensor imaging and tractography of the spinal cord
T2 - From experimental studies to clinical application
AU - Fujiyoshi, Kanehiro
AU - Konomi, Tsunehiko
AU - Yamada, Masayuki
AU - Hikishima, Keigo
AU - Tsuji, Osahiko
AU - Komaki, Yuji
AU - Momoshima, Suketaka
AU - Toyama, Yoshiaki
AU - Nakamura, Masaya
AU - Okano, Hideyuki
N1 - Funding Information:
This work was supported by grants from Grants-in-Aid for Scientific Research from JSPS and the Ministry of Education, Culture, Sports, Science and Technology of Japan (MEXT) , the project for realization of regenerative medicine and support for the core institutes for iPS cell research from MEXT, the General Insurance Association of Japan, the Funding Program for World-leading Innovative R&D on Science and Technology, and a grant-in-aid from Global COE Programs of MEXT to Keio University.
PY - 2013/4
Y1 - 2013/4
N2 - Diffusion-weighted magnetic resonance imaging provides detailed information about biological structures. In particular, diffusion tensor imaging and diffusion tensor tractography (DTT) are powerful tools for evaluating white matter fibers in the central nervous system. We previously established a reproducible spinal cord injury model in adult common marmosets and showed that DTT could be used to trace the neural tracts in the intact and injured spinal cord of these animals in vivo. Recently, many reports using DTT to analyze the spinal cord area have been published. Based on the findings from our experimental studies, we are now routinely performing DTT of the human spinal cord in the clinic. In this review we outline the basic principles of DTT, and describe the characteristics, limitations, and future uses of DTT to examine the spinal cord.
AB - Diffusion-weighted magnetic resonance imaging provides detailed information about biological structures. In particular, diffusion tensor imaging and diffusion tensor tractography (DTT) are powerful tools for evaluating white matter fibers in the central nervous system. We previously established a reproducible spinal cord injury model in adult common marmosets and showed that DTT could be used to trace the neural tracts in the intact and injured spinal cord of these animals in vivo. Recently, many reports using DTT to analyze the spinal cord area have been published. Based on the findings from our experimental studies, we are now routinely performing DTT of the human spinal cord in the clinic. In this review we outline the basic principles of DTT, and describe the characteristics, limitations, and future uses of DTT to examine the spinal cord.
KW - Common marmoset
KW - Diffusion tensor imaging
KW - Diffusion tensor tractography
KW - Diffusion-weighted imaging
KW - Magnetic resonance imaging
KW - Pyramidal decussation
KW - Spinal cord
KW - Spinal cord injury
KW - Tract based spatial statistics
KW - Voxel based analysis
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U2 - 10.1016/j.expneurol.2012.07.015
DO - 10.1016/j.expneurol.2012.07.015
M3 - Review article
C2 - 22868199
AN - SCOPUS:84875053312
SN - 0014-4886
VL - 242
SP - 74
EP - 82
JO - Experimental Neurology
JF - Experimental Neurology
ER -