Dinucleotide repeat polymorphism in the third intron of the NRAMP2/DMT1 gene

Fumio Kishi; Seitaro Fujishima; Mitsuaki Tabuchi

doi:10.1007/s100380050195

Dinucleotide repeat polymorphism in the third intron of the NRAMP2/DMT1 gene

Fumio Kishi, Seitaro Fujishima, Mitsuaki Tabuchi

Center for General Medicine Education

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Nramp1 (natural resistance-associated macrophage protein 1), encoding a polytropic integral membrane protein, was isolated as a candidate of the mouse Lsh/Ity/Bcg locus, which regulates macrophage activation for antimicrobial activity against intracellular pathogens. The NRAMP2 gene was cloned from human genome as a homologue of NRAMP1. We found a polymorphic dinucleotide repeat in the third intron of the NRAMP2 gene. This polymorphism will be a useful genetic marker to study disease associated with susceptibility to infection with intracellular pathogens.

Original language	English
Pages (from-to)	425-427
Number of pages	3
Journal	Journal of Human Genetics
Volume	44
Issue number	6
DOIs	https://doi.org/10.1007/s100380050195
Publication status	Published - 1999 Jan 1

Keywords

DMT1
Dinucleotide repeat
Iron transport
NRAMP2

ASJC Scopus subject areas

Genetics
Genetics(clinical)

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1007/s100380050195

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title = "Dinucleotide repeat polymorphism in the third intron of the NRAMP2/DMT1 gene",

abstract = "Nramp1 (natural resistance-associated macrophage protein 1), encoding a polytropic integral membrane protein, was isolated as a candidate of the mouse Lsh/Ity/Bcg locus, which regulates macrophage activation for antimicrobial activity against intracellular pathogens. The NRAMP2 gene was cloned from human genome as a homologue of NRAMP1. We found a polymorphic dinucleotide repeat in the third intron of the NRAMP2 gene. This polymorphism will be a useful genetic marker to study disease associated with susceptibility to infection with intracellular pathogens.",

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AU - Kishi, Fumio

AU - Fujishima, Seitaro

AU - Tabuchi, Mitsuaki

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Y1 - 1999/1/1

N2 - Nramp1 (natural resistance-associated macrophage protein 1), encoding a polytropic integral membrane protein, was isolated as a candidate of the mouse Lsh/Ity/Bcg locus, which regulates macrophage activation for antimicrobial activity against intracellular pathogens. The NRAMP2 gene was cloned from human genome as a homologue of NRAMP1. We found a polymorphic dinucleotide repeat in the third intron of the NRAMP2 gene. This polymorphism will be a useful genetic marker to study disease associated with susceptibility to infection with intracellular pathogens.

AB - Nramp1 (natural resistance-associated macrophage protein 1), encoding a polytropic integral membrane protein, was isolated as a candidate of the mouse Lsh/Ity/Bcg locus, which regulates macrophage activation for antimicrobial activity against intracellular pathogens. The NRAMP2 gene was cloned from human genome as a homologue of NRAMP1. We found a polymorphic dinucleotide repeat in the third intron of the NRAMP2 gene. This polymorphism will be a useful genetic marker to study disease associated with susceptibility to infection with intracellular pathogens.

KW - DMT1

KW - Dinucleotide repeat

KW - Iron transport

KW - NRAMP2

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Dinucleotide repeat polymorphism in the third intron of the NRAMP2/DMT1 gene

Abstract

Keywords

ASJC Scopus subject areas

UN SDGs

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