Dinucleotide repeat polymorphism in the third intron of the NRAMP2/DMT1 gene

Fumio Kishi, Seitaro Fujishima, Mitsuaki Tabuchi

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Nramp1 (natural resistance-associated macrophage protein 1), encoding a polytropic integral membrane protein, was isolated as a candidate of the mouse Lsh/Ity/Bcg locus, which regulates macrophage activation for antimicrobial activity against intracellular pathogens. The NRAMP2 gene was cloned from human genome as a homologue of NRAMP1. We found a polymorphic dinucleotide repeat in the third intron of the NRAMP2 gene. This polymorphism will be a useful genetic marker to study disease associated with susceptibility to infection with intracellular pathogens.

Original languageEnglish
Pages (from-to)425-427
Number of pages3
JournalJournal of Human Genetics
Issue number6
Publication statusPublished - 1999 Jan 1


  • DMT1
  • Dinucleotide repeat
  • Iron transport
  • NRAMP2

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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