Direct asymmetric α-allylation of ketones with allylic alcohols Via Pd/enamine cooperative function

Shigeo Yasuda; Naoya Kumagai; Masakatsu Shibasaki

doi:10.3987/COM-12-S(N)34

Direct asymmetric α-allylation of ketones with allylic alcohols Via Pd/enamine cooperative function

Shigeo Yasuda, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

Abstract

Direct asymmetric α-allylation of ketones with allylic alcohols is described. The combination of palladium with a new phosphine ligand bearing a chiral proline moiety promoted the reaction to afford the corresponding α-allylated ketones in moderate yield and enantioselectivity.

Original language	English
Pages (from-to)	745-757
Number of pages	13
Journal	Heterocycles
Volume	86
Issue number	1
DOIs	https://doi.org/10.3987/COM-12-S(N)34
Publication status	Published - 2012
Externally published	Yes

ASJC Scopus subject areas

Analytical Chemistry
Pharmacology
Organic Chemistry

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title = "Direct asymmetric α-allylation of ketones with allylic alcohols Via Pd/enamine cooperative function",

abstract = "Direct asymmetric α-allylation of ketones with allylic alcohols is described. The combination of palladium with a new phosphine ligand bearing a chiral proline moiety promoted the reaction to afford the corresponding α-allylated ketones in moderate yield and enantioselectivity.",

author = "Shigeo Yasuda and Naoya Kumagai and Masakatsu Shibasaki",

year = "2012",

doi = "10.3987/COM-12-S(N)34",

language = "English",

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journal = "Heterocycles",

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publisher = "Japan Institute of Heterocyclic Chemistry",

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T1 - Direct asymmetric α-allylation of ketones with allylic alcohols Via Pd/enamine cooperative function

AU - Yasuda, Shigeo

AU - Kumagai, Naoya

AU - Shibasaki, Masakatsu

PY - 2012

Y1 - 2012

N2 - Direct asymmetric α-allylation of ketones with allylic alcohols is described. The combination of palladium with a new phosphine ligand bearing a chiral proline moiety promoted the reaction to afford the corresponding α-allylated ketones in moderate yield and enantioselectivity.

AB - Direct asymmetric α-allylation of ketones with allylic alcohols is described. The combination of palladium with a new phosphine ligand bearing a chiral proline moiety promoted the reaction to afford the corresponding α-allylated ketones in moderate yield and enantioselectivity.

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UR - http://www.scopus.com/inward/citedby.url?scp=84879523541&partnerID=8YFLogxK

U2 - 10.3987/COM-12-S(N)34

DO - 10.3987/COM-12-S(N)34

M3 - Article

AN - SCOPUS:84879523541

SN - 0385-5414

VL - 86

SP - 745

EP - 757

JO - Heterocycles

JF - Heterocycles

IS - 1

ER -

Direct asymmetric α-allylation of ketones with allylic alcohols Via Pd/enamine cooperative function

Abstract

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