Direct catalytic asymmetric mannich-type reaction of α-sulfanyl lactones

Sho Takechi, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


Catalytic asymmetric Mannich-type reactions of α-sulfanyl lactones to aldimines were promoted by a chiral Ag complex/DBU binary catalyst. The reaction proceeded in a syn-selective manner in high enantioselectivity. Alkylative activation of the sulfide of the Mannich adduct allowed for the formation of trisubstituted aziridines.

Original languageEnglish
Pages (from-to)2632-2635
Number of pages4
JournalOrganic Letters
Issue number11
Publication statusPublished - 2013 Jun 7
Externally publishedYes

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry


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