Direct enzymatic synthesis of a polyester with free pendant mercapto groups

Makoto Kato, Kazunobu Toshima, Shuichi Matsumura

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


An aliphatic polyester with free pendant mercapto groups was prepared by direct lipase-catalyzed polycondensation of hexane-1,6-diol and dimethyl 2-mercaptosuccinate. The polycondensation reaction using immobilized lipase from Candida antarctica (lipase CA) was carried out in bulk at 70 °C without any formation of disulfide or thioester linkages to produce the corresponding polyester with Mw = 14000 g/mol in high yield. The content of free mercapto groups in the polyester could be controlled by copolymerization with other monomers. The obtained polyester was easily cross-linked to form gels by the air oxidation of the pendant thiols to disulfides in dimethyl sulfoxide.

Original languageEnglish
Pages (from-to)366-373
Number of pages8
Issue number2
Publication statusPublished - 2009 Feb 9

ASJC Scopus subject areas

  • Bioengineering
  • Biomaterials
  • Polymers and Plastics
  • Materials Chemistry


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