Direct induction of neural cells from somatic cells

Wado Akamatsu, Hideyuki Okano

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


Neural stem cells (NSCs) are a promising source for cell therapy in spinal cord injury (SCI). However, the preparation of NSCs from human-induced pluripotent stem cells (iPSCs) is time-consuming, and the preparation of autologous NSCs within the subacute phase after SCI is not possible at present. Previously, we succeeded in inducing self-renewing and tri-potent NSCs, which we designated induced NSCs (iNSCs), directly from mouse and human fibroblasts using Oct4, Sox2, Klf4, and c-Myc without clonal isolation of iPSCs. These iNSCs, which are generated without complete reprogramming into iPSCs, differentiate into neural lineage cells more rapidly than differentiation of similar cells from iPSCs. In addition to providing an overview of the generation and properties of iNSCs, we describe the application of new reprogramming technologies in neuroscience and disease modeling, in the derivation of induced neuronal cells.

Original languageEnglish
Title of host publicationRosenberg’s Molecular and Genetic Basis of Neurological and Psychiatric Disease
Subtitle of host publicationVolume 1
Number of pages7
ISBN (Electronic)9780128139554
Publication statusPublished - 2020 Jan 1


  • Direct induction
  • Induced neuronal (iN) cells
  • Induced pluripotent stem cells (iPSCs)
  • Neural stem cells (NSCs)
  • Reprogramming

ASJC Scopus subject areas

  • Medicine(all)


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