Direct proline-catalyzed asymmetric α-aminoxylation of ketones

Yujiro Hayashi, Junichiro Yamaguchi, Tatsunobu Sumiya, Mitsuru Shoji

Research output: Contribution to journalArticlepeer-review

279 Citations (Scopus)


Nitrosobenzene is the oxygen source in the direct catalytic enantioselective α-aminoxylation of ketones catalyzed by L-proline [Eq. (1)]. Versatile α-aminoxylated ketones are obtained in high yield and with excellent enantioselectivities.

Original languageEnglish
Pages (from-to)1112-1115
Number of pages4
JournalAngewandte Chemie - International Edition
Issue number9
Publication statusPublished - 2004 Feb 20
Externally publishedYes


  • Asymmetric catalysis
  • Ketones
  • Oxidation
  • Proline

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)


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