Distinct neuropsychological profiles of three major symptom dimensions in obsessive-compulsive disorder

Nobuhiko Hashimoto, Shutaro Nakaaki, Ichiro M. Omori, Junko Fujioi, Yuka Noguchi, Yoshie Murata, Junko Sato, Hiroshi Tatsumi, Katsuyoshi Torii, Masaru Mimura, Toshi A. Furukawa

Research output: Contribution to journalArticlepeer-review

50 Citations (Scopus)


Recent neuroimaging studies have suggested that different symptom dimensions are mediated by partially distinct neural systems in obsessive-compulsive disorder (OCD). However, the correlations between neuropsychological profiles and symptom dimensions in OCD are unknown. The aim of this study was to examine the extent to which OCD symptom dimensions were associated with episodic memory and attention and executive functions. The symptom dimensions of 63 patients with OCD were assessed using both the Padua Inventory and the Y-BOCS symptom checklist. Then, we administered the Logical Memory (LM) subset of the Wechsler Memory Scale-Revised (WMR-R) test and evaluated inhibition (Stroop test, Trail Making test) and cognitive flexibility (Digit Symbol test, Letter Fluency, and Category Fluency). While associations were observed between scores on the contamination/cleaning dimension and better performances on the LM and Trail Making tests, associations were also observed between scores on the aggressive/checking dimension and poorer performances on the Trail Making test. In addition, we found that scores on the symmetry/ordering dimension were associated with poorer performances on the LM and Trail Making tests. Our results support the hypothesis that different symptoms may represent distinct and partially overlapping neurocognitive networks in OCD patients.

Original languageEnglish
Pages (from-to)166-173
Number of pages8
JournalPsychiatry Research
Issue number1-2
Publication statusPublished - 2011 May 15
Externally publishedYes


  • Attention and executive functions
  • Neuropsychological profiles
  • Obsessions/checking
  • Obsessive-compulsive disorder
  • Padua Inventory
  • Symmetry/ordering
  • Verbal memory
  • Y-BOCS symptom checklist

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry


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