Distribution of tight junctions in the primate cochlear lateral wall

Tsubasa Saeki, Makoto Hosoya, Shinsuke Shibata, Hideyuki Okano, Masato Fujioka, Kaoru Ogawa

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


The blood-labyrinth barrier (BLB) is a major structure that separates the inner ear from the systemic blood circulation. Many drugs cannot access the inner ear because of their inability to cross the BLB. In the cochlea, the BLB is mainly distributed in the lateral wall. However, the ultrastructure of the cochlear lateral wall, including the distribution of tight junctions (TJs), which are its main component, has not been thoroughly examined in primates. This study investigated the distribution of TJs in the cochlear lateral wall of the common marmoset by performing immunohistochemistry for TJ markers and transmission electron microscopy. As previously reported in rodents, TJs were distributed at the lumenal side of stria marginal cells and basal cells. In outer sulcus cells, which are more developed in primates than in rodents, TJs were distributed at the side with the endolymph but not at the side with the spiral ligament, where many capillaries were located. These findings indicate that drugs and small compounds circulating systemically in the blood can easily access outer sulcus cells, but have a limited ability to enter endolymph. No structural differences were detected between species, indicating that the in vivo distribution of drugs in cochlear lateral wall cells, including outer sulcus cells, in primates can be predicted by performing rodent experiments.

Original languageEnglish
Article number134686
JournalNeuroscience Letters
Publication statusPublished - 2020 Jan 19


  • Blood-labyrinth barrier
  • Endolymph
  • Marmoset
  • Outer sulcus cell
  • Tight junction

ASJC Scopus subject areas

  • General Neuroscience


Dive into the research topics of 'Distribution of tight junctions in the primate cochlear lateral wall'. Together they form a unique fingerprint.

Cite this