DNA diagnosis of hydatidiform mole using the polymerase chain reaction

Ryuichi Fukuyama, Mizuho Takata, Jun Kudoh, Kosuke Sakai, Shozo Tamura, Nobuyoshi Shimizu

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


We have used the polymerase chain reaction (PCR) technique for the diagnosis of hydatidiform mole, a trophoblastic disease. For this, we targeted the hypervariable 3′ flanking region of the APOB gene (APOB/ VNTR) because of its high heterozygosity index (0.61) in the Japanese population. We examined seven clinical cases which were tentatively diagnosed as hydatidiform moles. Five of these revealed DNA segments unique to the paternal APOB allele, allowing us to diagnose a complete mole. The PCR technique for targeting the APOB/VNTR appears useful for early diagnosis of hydatidiform mole.

Original languageEnglish
Pages (from-to)216-218
Number of pages3
JournalHuman genetics
Issue number2
Publication statusPublished - 1991 Jun
Externally publishedYes

ASJC Scopus subject areas

  • Genetics
  • Genetics(clinical)


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