Does neuroinflammation induce systemic aging?

Research output: Contribution to journalReview articlepeer-review


A recent article published in Nature presents intriguing data suggesting that the activation of neuronal nuclear factor-κB (NF-κB) in the mediobasal hypothalamus (MBH) causes systemic aging through reduced secretion of gonadotropin-releasing hormone, an anti-aging hormone. Microglial inflammation in MBH also seems to induce neuronal NF-κB. These results raise the possibility that neuroinflammation orchestrates systemic aging.

Original languageEnglish
Pages (from-to)155-156
Number of pages2
JournalClinical and Experimental Neuroimmunology
Issue number2
Publication statusPublished - 2013 Aug

ASJC Scopus subject areas

  • Neuroscience (miscellaneous)
  • Immunology
  • Immunology and Microbiology (miscellaneous)
  • Clinical Neurology


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