Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation

Kaori Uchino; Lam Vu Quang; Shohei Mizuno; Tomohiro Horio; Hidesuke Yamamoto; Ichiro Hanamura; Yoshihisa Kodera; J. Luis Espinoza; Makoto Onizuka; Koichi Kashiwase; Yasuo Morishima; Takahiro Fukuda; Noriko Doki; Koichi Miyamura; Takehiko Mori; Eriko Morishita; Shinji Nakao; Akiyoshi Takami

doi:10.1038/s41435-021-00122-y

Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation

Kaori Uchino, Lam Vu Quang, Shohei Mizuno, Tomohiro Horio, Hidesuke Yamamoto, Ichiro Hanamura, Yoshihisa Kodera, J. Luis Espinoza, Makoto Onizuka, Koichi Kashiwase, Yasuo Morishima, Takahiro Fukuda, Noriko Doki, Koichi Miyamura, Takehiko Mori, Eriko Morishita, Shinji Nakao, Akiyoshi Takami

Department of Internal Medicine (Hematology)

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

UNC-93 homolog B1 (UNC93B1) is a key regulator of toll-like receptors (TLRs), pattern recognition receptors that sense invading pathogens and manage the innate immune response and deliver them from the endoplasmic reticulum to their respective endosomal signaling compartments. Several types of TLRs are known to contribute to the inflammatory process after allogeneic hematopoietic stem cell transplantation (SCT), so UNC93B1 might play integral roles there. We investigated the influence of the UNC93B1 single-nucleotide polymorphism (SNP) rs308328 (T>C) on transplant outcomes in a cohort of 237 patients undergoing unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. The donor UNC93B1 C/C genotype was associated with a better 3-year overall survival than the donor UNC93B1 C/T or T/T genotype. An analysis of the UNC93B1 rs308328 genotype may therefore be useful for selecting the donor, estimating the prognosis, and creating therapeutic strategies after allogeneic SCT.

Original language	English
Pages (from-to)	35-43
Number of pages	9
Journal	Genes and Immunity
Volume	22
Issue number	1
DOIs	https://doi.org/10.1038/s41435-021-00122-y
Publication status	Published - 2021 May

ASJC Scopus subject areas

Immunology
Genetics
Genetics(clinical)

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Uchino, K., Vu Quang, L., Mizuno, S., Horio, T., Yamamoto, H., Hanamura, I., Kodera, Y., Luis Espinoza, J., Onizuka, M., Kashiwase, K., Morishima, Y., Fukuda, T., Doki, N., Miyamura, K., Mori, T., Morishita, E., Nakao, S., & Takami, A. (2021). Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation. Genes and Immunity, 22(1), 35-43. https://doi.org/10.1038/s41435-021-00122-y

Uchino, K, Vu Quang, L, Mizuno, S, Horio, T, Yamamoto, H, Hanamura, I, Kodera, Y, Luis Espinoza, J, Onizuka, M, Kashiwase, K, Morishima, Y, Fukuda, T, Doki, N, Miyamura, K, Mori, T, Morishita, E, Nakao, S & Takami, A 2021, 'Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation', Genes and Immunity, vol. 22, no. 1, pp. 35-43. https://doi.org/10.1038/s41435-021-00122-y

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title = "Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation",

abstract = "UNC-93 homolog B1 (UNC93B1) is a key regulator of toll-like receptors (TLRs), pattern recognition receptors that sense invading pathogens and manage the innate immune response and deliver them from the endoplasmic reticulum to their respective endosomal signaling compartments. Several types of TLRs are known to contribute to the inflammatory process after allogeneic hematopoietic stem cell transplantation (SCT), so UNC93B1 might play integral roles there. We investigated the influence of the UNC93B1 single-nucleotide polymorphism (SNP) rs308328 (T>C) on transplant outcomes in a cohort of 237 patients undergoing unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. The donor UNC93B1 C/C genotype was associated with a better 3-year overall survival than the donor UNC93B1 C/T or T/T genotype. An analysis of the UNC93B1 rs308328 genotype may therefore be useful for selecting the donor, estimating the prognosis, and creating therapeutic strategies after allogeneic SCT.",

author = "Kaori Uchino and {Vu Quang}, Lam and Shohei Mizuno and Tomohiro Horio and Hidesuke Yamamoto and Ichiro Hanamura and Yoshihisa Kodera and {Luis Espinoza}, J. and Makoto Onizuka and Koichi Kashiwase and Yasuo Morishima and Takahiro Fukuda and Noriko Doki and Koichi Miyamura and Takehiko Mori and Eriko Morishita and Shinji Nakao and Akiyoshi Takami",

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doi = "10.1038/s41435-021-00122-y",

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AU - Uchino, Kaori

AU - Vu Quang, Lam

AU - Mizuno, Shohei

AU - Horio, Tomohiro

AU - Yamamoto, Hidesuke

AU - Hanamura, Ichiro

AU - Kodera, Yoshihisa

AU - Luis Espinoza, J.

AU - Onizuka, Makoto

AU - Kashiwase, Koichi

AU - Morishima, Yasuo

AU - Fukuda, Takahiro

AU - Doki, Noriko

AU - Miyamura, Koichi

AU - Mori, Takehiko

AU - Morishita, Eriko

AU - Nakao, Shinji

AU - Takami, Akiyoshi

PY - 2021/5

Y1 - 2021/5

N2 - UNC-93 homolog B1 (UNC93B1) is a key regulator of toll-like receptors (TLRs), pattern recognition receptors that sense invading pathogens and manage the innate immune response and deliver them from the endoplasmic reticulum to their respective endosomal signaling compartments. Several types of TLRs are known to contribute to the inflammatory process after allogeneic hematopoietic stem cell transplantation (SCT), so UNC93B1 might play integral roles there. We investigated the influence of the UNC93B1 single-nucleotide polymorphism (SNP) rs308328 (T>C) on transplant outcomes in a cohort of 237 patients undergoing unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. The donor UNC93B1 C/C genotype was associated with a better 3-year overall survival than the donor UNC93B1 C/T or T/T genotype. An analysis of the UNC93B1 rs308328 genotype may therefore be useful for selecting the donor, estimating the prognosis, and creating therapeutic strategies after allogeneic SCT.

AB - UNC-93 homolog B1 (UNC93B1) is a key regulator of toll-like receptors (TLRs), pattern recognition receptors that sense invading pathogens and manage the innate immune response and deliver them from the endoplasmic reticulum to their respective endosomal signaling compartments. Several types of TLRs are known to contribute to the inflammatory process after allogeneic hematopoietic stem cell transplantation (SCT), so UNC93B1 might play integral roles there. We investigated the influence of the UNC93B1 single-nucleotide polymorphism (SNP) rs308328 (T>C) on transplant outcomes in a cohort of 237 patients undergoing unrelated HLA-matched bone marrow transplantation (BMT) for hematologic malignancies through the Japan Marrow Donor Program. The donor UNC93B1 C/C genotype was associated with a better 3-year overall survival than the donor UNC93B1 C/T or T/T genotype. An analysis of the UNC93B1 rs308328 genotype may therefore be useful for selecting the donor, estimating the prognosis, and creating therapeutic strategies after allogeneic SCT.

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Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation

Abstract

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