TY - GEN
T1 - Double-layer collagen microtube for perfusable heterogeneous culture
AU - Itai, Shun
AU - Onoe, Hiroaki
N1 - Funding Information:
This work was partly supported by Grant-in Aid for Scientific Research (B) (26289060), Japan Society for the Promotion of Science (JSPS), Japan..
Publisher Copyright:
© 17CBMS-0001.
PY - 2020
Y1 - 2020
N2 - We present a double-layer collagen microtube device for in vitro perfusable multilayered 3D cell culture. Thicknesses of the collagen layers in the microtube can flexibly designed, and heterogeneous types of cells can be co-cultured in each collagen layer or surfaces. Moreover, while our collagen tube is directly attached to silicone tubes, the collagen microtube can be easily connected to an external pump system for perfusion culture. We believe that our device could help easy fabrication of various tissue models mimicking in vivo, especially blood vessel models or vascularized skin models, and contribute to the development of pharmacokinetic testing platforms and regenerative medicine.
AB - We present a double-layer collagen microtube device for in vitro perfusable multilayered 3D cell culture. Thicknesses of the collagen layers in the microtube can flexibly designed, and heterogeneous types of cells can be co-cultured in each collagen layer or surfaces. Moreover, while our collagen tube is directly attached to silicone tubes, the collagen microtube can be easily connected to an external pump system for perfusion culture. We believe that our device could help easy fabrication of various tissue models mimicking in vivo, especially blood vessel models or vascularized skin models, and contribute to the development of pharmacokinetic testing platforms and regenerative medicine.
KW - 3D Tissue Engineering
KW - Co-Culture
KW - Collagen
KW - Vascularize
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M3 - Conference contribution
AN - SCOPUS:85079674874
T3 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
SP - 1137
EP - 1138
BT - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
PB - Chemical and Biological Microsystems Society
T2 - 21st International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2017
Y2 - 22 October 2017 through 26 October 2017
ER -