TY - JOUR
T1 - “Drop-slip” bulk sample flow on fully inkjet-printed microfluidic paper-based analytical device
AU - Henares, Terence G.
AU - Yamada, Kentaro
AU - Takaki, Shunsuke
AU - Suzuki, Koji
AU - Citterio, Daniel
N1 - Funding Information:
The authors thank Prof. Koichi Asakura for helpful discussion, and Dr. Yuki Hiruta for measuring the ζ-potential of the nanoparticle inks. This work was financially supported by the Medical Research and Development Programs Focused on Technology Transfer: Development of Advanced Measurement and Analysis Systems (SENTAN) by the Japan Agency for Medical Research and Development (AMED).
Publisher Copyright:
© 2017 Elsevier B.V.
PY - 2017
Y1 - 2017
N2 - With “drop-slip” (DS) bulk liquid flow on a fully inkjet-printed microfluidic paper-based analytical device (μPAD), a new method for the rapid transport of sample liquid is presented. The main driving force for DS flow is the slip flow of fluid on wetted porous cellulose acting as a lubricated surface, which is predominantly influenced by the width of the hydrophilic channel and the surface tension of the sample liquid. The application of DS flow is demonstrated by a model colorimetric metal assay (Zn2+, Cu2+, Fe2+) with inkjet-deposited indicators on a μPAD with optimized channel dimensions of 2 mm width and 110 μm height. The presence of bulk liquid on the entire device does not result in any mixing of assay components across adjacent sensing regions connected by microfluidic channels. DS flow is a useful alternative sample liquid transport method for μPADs, allowing to perform multiple fully independent assays with enlarged sample volumes without requiring any significant variation in device design and fabrication.
AB - With “drop-slip” (DS) bulk liquid flow on a fully inkjet-printed microfluidic paper-based analytical device (μPAD), a new method for the rapid transport of sample liquid is presented. The main driving force for DS flow is the slip flow of fluid on wetted porous cellulose acting as a lubricated surface, which is predominantly influenced by the width of the hydrophilic channel and the surface tension of the sample liquid. The application of DS flow is demonstrated by a model colorimetric metal assay (Zn2+, Cu2+, Fe2+) with inkjet-deposited indicators on a μPAD with optimized channel dimensions of 2 mm width and 110 μm height. The presence of bulk liquid on the entire device does not result in any mixing of assay components across adjacent sensing regions connected by microfluidic channels. DS flow is a useful alternative sample liquid transport method for μPADs, allowing to perform multiple fully independent assays with enlarged sample volumes without requiring any significant variation in device design and fabrication.
KW - Free surface flow
KW - Inkjet printing
KW - Microfluidic paper-based analytical device
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U2 - 10.1016/j.snb.2017.01.088
DO - 10.1016/j.snb.2017.01.088
M3 - Article
AN - SCOPUS:85010830921
SN - 0925-4005
VL - 244
SP - 1129
EP - 1137
JO - Sensors and Actuators, B: Chemical
JF - Sensors and Actuators, B: Chemical
ER -