Drug re-profiling strategy for drug development

Tohru Mizushima, Takushi Namba

Research output: Contribution to journalArticlepeer-review


As a new strategy for drug discovery and development, we propose here the establishment of drug re-profiling strategy. In this strategy, the actions of existing medicines, whose safety and pharmacokinetic effects in humans have been confirmed already, are examined comprehensively at the molecular level and the results are used for the development of new medicines. For example, identification of the mechanisms underlying the side effects of medicines enables us to develop safer drugs. The results can also be used for developing existing drugs for use as medicines in treatment of other diseases. Promoting this research strategy could provide breakthroughs in drug discovery and development by pharmaceutical companies.

Original languageEnglish
Pages (from-to)106-112
Number of pages7
JournalDrug Delivery System
Issue number2
Publication statusPublished - 2011
Externally publishedYes


  • Drug discovery and development
  • Drug re-profiling
  • Existing medicines
  • Pharmaceutical company
  • Safety

ASJC Scopus subject areas

  • Pharmaceutical Science


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