Dry eye after haematopoietic stem cell transplantation

Yoko Ogawa, Shinichiro Okamoto, Masatoshi Wakui, Reiko Watanabe, Masakazu Yamada, Mami Yoshino, Masafumi Ono, Hao Yung Yang, Yukihiko Mashima, Yoshihisa Oguchi, Yasuo Ikeda, Kazuo Tsubota

Research output: Contribution to journalArticlepeer-review

197 Citations (Scopus)


Aims - To determine the incidence, natural course, and severity of dry eye occurring or worsening after haematopoietic stem cell transplantation (SCT). Methods - At a tertiary care hospital, 53 patients undergoing allogeneic or autologous SCT followed by at least 180 days of follow up were studied prospectively. Examination included grading of symptoms of dry eye, evaluation of ocular surface, tear break up time, and Schirmer tests with and without nasal stimulation. Meibomian gland secretion was also examined using a slit lamp while applying steady digital pressure. Results - Of the 53 patients, 44 received allografts. Half of these patients (22) developed dry eye or their pre-existing dry eye worsened after SCT, while none of nine autograft recipients did. Onset of dry eye was 171 (SD 59) days after SCT. Two types of dry eye occurred. One (n = 10) was severe with ocular surface findings resembling Sjogren's syndrome and reduction of reflex tearing soon after onset. A mild type (n = 12) had unimpaired reflex tearing. Meibomian gland dysfunction (MGD) was more frequent and severe in patients with dry eye and chronic graft versus host disease (GVHD), and overall severity of dry eye was greater in patients with MGD and chronic GVHD. Conclusions - Dry eye after SCT occurred only in allograft recipients, and was not evident in autograft recipients. The severe form of dry eye had a tendency to develop rapidly. Further study on the prediction and treatment of severe dry eye after SCT is necessary.

Original languageEnglish
Pages (from-to)1125-1130
Number of pages6
JournalBritish Journal of Ophthalmology
Issue number10
Publication statusPublished - 1999

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience


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