TY - JOUR
T1 - E-CELL project
T2 - Towards integrative simulation of cellular processes
AU - Tomita, Masaru
AU - Hashimoto, Kenta
AU - Takahashi, Koichi
AU - Matsuzaki, Yuri
AU - Matsushima, Ryo
AU - Saito, Kanako
AU - Yugi, Katsuyuki
AU - Miyoshi, Fumihiko
AU - Nakano, Hisako
AU - Tanida, Sakura
AU - Saito, Yusuke
AU - Kawase, Akiko
AU - Watanabe, Naoko
AU - Shimizu, Thomas S.
AU - Nakayama, Yoichi
PY - 2000
Y1 - 2000
N2 - The E-CELL project was launched in 1996 at Keio University in order to model and simulate various cellular processes with the ultimate goal of simulating the cell as a whole. The first version of the E-CELL simulation system, which is a generic software package for cell modeling, was completed in 1997. The E-CELL system enables us to model not only metabolic pathways but also other higher-order cellular processes such as protein synthesis and membrane transport within the same framework. These various processes can then be integrated into a single simulation model. Using the E-CELL system, we have successfully constructed a virtual cell with 127 genes sufficient for `self-support'. The gene set was selected from the genome of Mycoplasm genitalium, the organism having the smallest known genome. The set includes genes for transcription, translation, the glycolysis pathway for energy production, membrane transport, and the phospholipid biosynthesis pathway for membrane structure. The E-CELL system has been made available for beta testing from our website (http://www.e-cell.org).
AB - The E-CELL project was launched in 1996 at Keio University in order to model and simulate various cellular processes with the ultimate goal of simulating the cell as a whole. The first version of the E-CELL simulation system, which is a generic software package for cell modeling, was completed in 1997. The E-CELL system enables us to model not only metabolic pathways but also other higher-order cellular processes such as protein synthesis and membrane transport within the same framework. These various processes can then be integrated into a single simulation model. Using the E-CELL system, we have successfully constructed a virtual cell with 127 genes sufficient for `self-support'. The gene set was selected from the genome of Mycoplasm genitalium, the organism having the smallest known genome. The set includes genes for transcription, translation, the glycolysis pathway for energy production, membrane transport, and the phospholipid biosynthesis pathway for membrane structure. The E-CELL system has been made available for beta testing from our website (http://www.e-cell.org).
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U2 - 10.1007/BF03037563
DO - 10.1007/BF03037563
M3 - Article
AN - SCOPUS:18844475514
SN - 0288-3635
VL - 18
SP - 1
EP - 12
JO - New Generation Computing
JF - New Generation Computing
IS - 1
ER -