Early enteral nutrition shortens ICU stays

Ai Fujimoto, Katsunori Yoshihara, Takaya Tsubota, Yoshihito Sakata, Satoshi Hamada, Hiroshi Masuhara, Satoshi Yajima, Kazuyoshi Tamaki, Yumiko Shibata, Hiroshi Ito, Naoshi Kikuchi, Hitomi Yuzawa, Tomoharu Kawase, Yasunari Sakamoto, Mitsuru Honda, Yoshinori Igarashi, Yasukiyo Sumino

Research output: Contribution to journalArticlepeer-review


Background: Early enteral nutrition is effective in preventing bacterial translocation and suppressing the onset of multisystem organ failure (MSOF) and organopathy. We investigated the effect of early enteral nutrition on the duration of intensive care unit (ICU) stays. Methods: The study comprised 112 patients who stayed in our ICU for 10 days or longer during a recent 47-month period and were discharged alive. The patients were divided into 2 groups: one that was given enteral nutrients within 72 hours of admission to ICU (early starters, n = 26) and another that was given enteral nutrients later than 72 hours after admission to ICU (late starters, n = 86). We then compared the 2 groups with respect to the number of ICU days and the maximum total serum bilirubin value during the ICU stay. Results: As compared with the late starters, early starters required significantly fewer ICU days (p = 0.041) and had significantly lower maximum total bilirubin values (p = 0.006). There was a significant and positive correlation between the maximum total bilirubin value and duration of ICU stay (r = 0.435, p< 0.0001). Conclusion: Enteral nutrition started within 72 hours after admission is effective in suppressing hyperbilirubinemia and shortening ICU stays.

Original languageEnglish
Pages (from-to)110-115
Number of pages6
JournalJournal of the Medical Society of Toho University
Issue number2
Publication statusPublished - 2010 Mar
Externally publishedYes


  • Bacterial translocation
  • Early enteral nutrition
  • Number of icu days
  • Retrospective study
  • Total serum bilirubin

ASJC Scopus subject areas

  • Medicine(all)


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