TY - JOUR
T1 - Effect of diabetes and prediabetes on the development of disability and mortality among middle-aged Japanese adults
T2 - A 22-year follow up of NIPPON DATA90
AU - NIPPON DATA90 Research Group
AU - Tran Ngoc Hoang, Phap
AU - Kadota, Aya
AU - Yano, Yuichiro
AU - Harada, Akiko
AU - Hayakawa, Takehito
AU - Okamoto, Shohei
AU - Miyagawa, Naoko
AU - Kondo, Keiko
AU - Okukda, Nagako
AU - Kita, Yoshiuni
AU - Okayama, Akira
AU - Fujita, Yukihiro
AU - Maegawa, Hiroshi
AU - Miura, Katsuyuki
AU - Okamura, Tomonori
AU - Ueshima, Hirotsugu
N1 - Funding Information:
This study was supported by a Grant‐in‐Aid from the Ministry of Health, Labor and Welfare under the auspices of the Japanese Association for Cerebro‐cardiovascular Disease Control; a Research Grant for Cardiovascular Diseases (7A‐2) from the Ministry of Health, Labor and Welfare; and Health and Labor Sciences Research Grants, Japan (Comprehensive Research on Aging and Health [H11‐Chouju‐046, H14‐Chouju‐003, H17‐Chouju‐012, H19‐Chouju‐Ippan‐014] and Comprehensive Research on Life‐Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus [H22‐Junkankitou‐Seishuu‐Sitei‐017, H25‐Junkankitou‐Seishuu‐Sitei‐022, H30‐Junkankitou‐Sitei‐002, 21FA2002]). The authors thank all members of the Japanese Association of Public Health Center Directors and all staff of the public health centers that cooperated with our study.
Funding Information:
This study was supported by a Grant-in-Aid from the Ministry of Health, Labor and Welfare under the auspices of the Japanese Association for Cerebro-cardiovascular Disease Control; a Research Grant for Cardiovascular Diseases (7A-2) from the Ministry of Health, Labor and Welfare; and Health and Labor Sciences Research Grants, Japan (Comprehensive Research on Aging and Health [H11-Chouju-046, H14-Chouju-003, H17-Chouju-012, H19-Chouju-Ippan-014] and Comprehensive Research on Life-Style Related Diseases including Cardiovascular Diseases and Diabetes Mellitus [H22-Junkankitou-Seishuu-Sitei-017, H25-Junkankitou-Seishuu-Sitei-022, H30-Junkankitou-Sitei-002, 21FA2002]). The authors thank all members of the Japanese Association of Public Health Center Directors and all staff of the public health centers that cooperated with our study.
Publisher Copyright:
© 2022 The Authors. Journal of Diabetes Investigation published by Asian Association for the Study of Diabetes (AASD) and John Wiley & Sons Australia, Ltd.
PY - 2022/11
Y1 - 2022/11
N2 - Aims/Introduction: To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22-year period among middle-aged Japanese adults. Materials and Methods: Participants consisted of 1,788 adults aged 45–64 years at baseline from the cohort study National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 1990 (NIPPON DATA90). Disability, defined as having a decline in activities of daily living (ADL), was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22-year follow up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odds ratios (ORs) were obtained from four models that contained appropriate adjustment factors, such as age, sex, smoking status, drinking status, body mass index and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high-density lipoprotein), at baseline. Results: In the present study, 334 participants (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had a higher risk for disability (OR 1.43, 95% confidence interval [CI] 1.07–1.91 and OR 1.66, 95% CI 1.10–2.50, respectively) and for mortality (OR 1.56, 95% CI 1.16–2.08 and OR 1.77, 95% CI 1.18–2.65, respectively) than individuals with normal glucose tolerance. Conclusions: In middle-aged Japanese adults, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle-aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life.
AB - Aims/Introduction: To examine the association between diabetes and prediabetes at baseline, and disability, mortality over a 22-year period among middle-aged Japanese adults. Materials and Methods: Participants consisted of 1,788 adults aged 45–64 years at baseline from the cohort study National Integrated Project for Prospective Observation of Non-communicable Disease and its Trends in the Aged 1990 (NIPPON DATA90). Disability, defined as having a decline in activities of daily living (ADL), was assessed by a modified Katz questionnaire at four time points. Disability and death without disability for 22-year follow up were used as outcomes to test the association with a diagnosis of diabetes or prediabetes at baseline, using multinomial logistic regression. Adjusted odds ratios (ORs) were obtained from four models that contained appropriate adjustment factors, such as age, sex, smoking status, drinking status, body mass index and cardiovascular risk factors (hypertension, hypercholesterolemia, triglycerides, low serum high-density lipoprotein), at baseline. Results: In the present study, 334 participants (18.7%) reported at least one disability, and 350 (19.6%) were reported dead without observation of disability during follow up. Adjusting sex and other risk factors, participants with diabetes and prediabetes had a higher risk for disability (OR 1.43, 95% confidence interval [CI] 1.07–1.91 and OR 1.66, 95% CI 1.10–2.50, respectively) and for mortality (OR 1.56, 95% CI 1.16–2.08 and OR 1.77, 95% CI 1.18–2.65, respectively) than individuals with normal glucose tolerance. Conclusions: In middle-aged Japanese adults, individuals with diabetes and prediabetes were more likely to be associated with disability and mortality. Our findings suggest that prediabetes and diabetes in middle-aged adults should be paid more attention, and requires more intervention to prevent disability and mortality in later life.
KW - Disability
KW - Mortality
KW - Prediabetes
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U2 - 10.1111/jdi.13871
DO - 10.1111/jdi.13871
M3 - Article
C2 - 35717665
AN - SCOPUS:85134506683
SN - 2040-1116
VL - 13
SP - 1897
EP - 1904
JO - Journal of Diabetes Investigation
JF - Journal of Diabetes Investigation
IS - 11
ER -
