Abstract
In fasted mice, plasma glucose levels were reduced by intraperitoneal administration of enoxacin, lomefloxacin, or gatifloxacin (50 mg/kg). A lower dose of these fluoroquinolones (5 mg/kg) also reduced the plasma glucose (PG) levels in glucose-loaded mice. Ciprofloxacin and levofloxacin did not reduce these levels in either fasted or glucose-loaded mice. These results suggest that each fluoroquinolone has an individual hypoglycemic action, and fluoroquinolone administration after meals might reduce PG levels at lower doses.
Original language | English |
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Pages (from-to) | 109-111 |
Number of pages | 3 |
Journal | Journal of Infection and Chemotherapy |
Volume | 12 |
Issue number | 2 |
DOIs | |
Publication status | Published - 2006 Apr |
Externally published | Yes |
Keywords
- Enoxacin
- Gatifloxacin
- Hypoglycemia
- Lomefloxacin
- Mice
ASJC Scopus subject areas
- Microbiology (medical)
- Infectious Diseases
- Pharmacology (medical)