Effect of genetic risk factors and disease progression on the cerebrospinal fluid tau levels in Azheimer's disease

Hiroyuki Arai, Masanori Terajima, Masakazu Miura, Susumu Higuchi, Taro Muramatsu, Sachio Matsushita, Nobuo Machida, Takuma Nakagawa, Virginia M.Y. Lee, John Q. Trojanowski, Hidetada Sasaki

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19 Citations (Scopus)


OBJECTIVE: This study was undertaken to gain insights into the clinical utility of measuring cerebrospinal fluid tau protein (CSF-tau) to aid in the diagnosis of Alzheimer's disease (AD). SETTING: AD patients from Tohoku University Hospital, Sendai Japan were sampled. SUBJECTS AND METHODS: CSF- tau levels were examined by sandwich enzyme-linked immunosorbent assay in a total of 62 patients carrying different α1-antichymotrypsin (ACT) and presenilin-1 (PS-1) polymorphic alleles. Further, the CSF-tau levels were followed up on two occasions during the progression of the disease in 17 AD patients. RESULTS: There was no evident gradient for tau protein in CSF. Neither the ACT/A allele nor the PS4/1 allele affected the CSF-tau levels. Although CSF-tau levels changed to a variable extent over time, the CSF-tau levels were significantly increased (P < .01) during the follow-up period. Three of the AD patients demonstrated decreasing values, whereas 14 patients showed increasing values. Finally, these temporal changes in CSF-tau levels were not influenced by the apolipoprotein E ε4, ACT/A or PS-1/1 alleles during the progression of AD. CONCLUSION: Regardless of the mechanisms leading to the degeneration of neurons in AD, our findings provide further evidences that monitoring CSF-tau levels may provide useful information about AD irrespective of the background of genetic risks and disease progression.

Original languageEnglish
Pages (from-to)1228-1231
Number of pages4
JournalJournal of the American Geriatrics Society
Issue number10
Publication statusPublished - 1997 Oct
Externally publishedYes

ASJC Scopus subject areas

  • Geriatrics and Gerontology


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