TY - JOUR
T1 - Effect of insulin therapy on body fat distribution in NIDDM patients with secondary sulfonylurea failure
T2 - A preliminary report
AU - Takei, I.
AU - Takayama, S.
AU - Yamauchi, A.
AU - Nakamoto, S.
AU - Kitamura, Y.
AU - Katsukawa, F.
AU - Yamazaki, H.
AU - Saruta, T.
AU - Inoue, S.
PY - 1998/2
Y1 - 1998/2
N2 - Objective: To clarify the influence of insulin therapy on body weight and fat distribution, we compared these parameters in five non-insulin dependent diabetes mellitus (NIDDM) patients, with secondary sulfonylurea failure, before and after insulin therapy. Body weight increased significantly after instituting insulin treatment. However, the visceral to subcutaneous fat (V/S) ratio decreased significantly due to a marked increase in S-fat without a change in V-fat. Insulin therapy necessitated by sulfonylurea failure does not appear to accelerate the atherogenic process in NIDDM patients as there is no increase in visceral fat.
AB - Objective: To clarify the influence of insulin therapy on body weight and fat distribution, we compared these parameters in five non-insulin dependent diabetes mellitus (NIDDM) patients, with secondary sulfonylurea failure, before and after insulin therapy. Body weight increased significantly after instituting insulin treatment. However, the visceral to subcutaneous fat (V/S) ratio decreased significantly due to a marked increase in S-fat without a change in V-fat. Insulin therapy necessitated by sulfonylurea failure does not appear to accelerate the atherogenic process in NIDDM patients as there is no increase in visceral fat.
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U2 - 10.1038/sj.ejcn.1600506
DO - 10.1038/sj.ejcn.1600506
M3 - Article
C2 - 9505163
AN - SCOPUS:0031931004
SN - 0954-3007
VL - 52
SP - 153
EP - 154
JO - European Journal of Clinical Nutrition
JF - European Journal of Clinical Nutrition
IS - 2
ER -
