Effect of meso-Hexestrol, a Synthetic Estrogen, on S-Tubulin

Aiko Hirata, Michio Matsuhashi, Yumiko Sakakibara, Taiko Oda, Yoshihiro Sato

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


We have reported that meso-hexestrol a synthetic estrogen, inhibits microtubule assembly and induces microtubule proteins into twisted ribbon structures. On the other hand, Serrano et a/. proved that S-tubulin, which lacks the C-terminal moiety of tubulin subunits, assembles into sheet structures in the absence of microtubule-associated proteins (MAPs). In the present investigation, we attempted to clarify whether meso-hexestrol could induce the ribbon structure from S-tubulin. meso-Hexestrol delayed the initiation of polymerization of S-tubulin into sheet structures in a dose-dependent manner below 50 pM. But the effect of meso-hexestrol on S-tubulin was reduced in the presence of either tau or microtubule-associated protein 2 (MAP2) in a MAPs-concentration-dependent manner. At concentrations higher than 100/im, meso-hexestrol inhibited the polymerization of S-tubulin into sheet structures, without forming ribbon structures. The present results may indicate that moso-hexestrol interacts with S-tubulin, and its interaction is affected by MAPs.

Original languageEnglish
Pages (from-to)3419-3422
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number12
Publication statusPublished - 1990 Jan 1


  • S-tubulin
  • meso-hexestrol
  • microtubule-associated protein
  • ribbon structure
  • synthetic estrogen

ASJC Scopus subject areas

  • Chemistry(all)
  • Drug Discovery


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