Effect of Platelet-Rich Plasma on Bone Grafting of Alveolar Clefts

Reiko Sakio, Yoshiaki Sakamoto, Hisao Ogata, Teruo Sakamoto, Takenobu Ishii, Kazuo Kishi

Research output: Contribution to journalArticlepeer-review

20 Citations (Scopus)


The purpose of this study was to evaluate the effectiveness of platelet-rich plasma (PRP) on the absorption of the bone graft in the alveolar cleft. Twenty-nine patients with alveolar clefts in unilateral cleft lip were examined; 6 were the control group and received iliac cancellous bone and marrow grafts without PRP, while the remaining 23 comprised the PRP group and received grafts with PRP. Quantitative evaluation of remaining bone was made by the computer-aided engineering with multidetector row computed tomography at 1 month and 1 year after surgery. Satisfactory bone bridging formation was observed in all patients. Two patients in control group and 1 patient in PRP group developed wound dehiscence with minor bone exposure. One year postoperatively, the canine was exposed and orthodontically guided into an ideal arch relation in all patients. The mean resorption ratio was 49.9 ± 17.2% and 44.9 ± 14.4% with no significant difference (P = 0.60). In conclusion, there is currently no evidence to suggest that autologous PRP is of value for effect on the bone resorption for alveolar bone graft.

Original languageEnglish
Pages (from-to)486-488
Number of pages3
JournalJournal of Craniofacial Surgery
Issue number2
Publication statusPublished - 2017


  • Alveolar cleft
  • bone graft
  • iliac bone
  • platelet-rich plasma

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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