TY - GEN
T1 - Effect of thickness of superficial tissues on the spatial sensitivity profile for optical imaging
AU - Okada, Eiji
N1 - Funding Information:
This work was partly supported by Grant-in-Aid for the 21st century Center of Excellence for Optical and Electronic Device Technology for Access Network from the Ministry of Education, Culture, Sport, Science and Technology in Japan, and a research grant from Tateisi Science and Technology Foundation.
Publisher Copyright:
© 2003 SPIE-OSA.
PY - 2003
Y1 - 2003
N2 - It is important for near-infrared imaging to estimate the sensitivity of detected signal to the change in absorption of tissue resulting from brain activation and the volume of tissue interrogated for a specific source-detector spacing. In this study, light propagation in adult head models is predicted by Monte Carlo simulation in order to investigate the effect of the thickness of the superficial tissues on the partial optical path length in the brain and on the spatial sensitivity profile. The effect of thickness of skull on the partial optical path length and spatial sensitivity profile is almost the same as that of the scalp. The effect of thickness of cerebrospinal fluid layer on the partial optical path length and spatial sensitivity profile is different from that of the scalp and skull. The partial optical path length mainly depends upon the depth of inner skull surface whilst the spatial sensitivity profile is considerably affected by the thickness of the cerebrospinal fluid layer.
AB - It is important for near-infrared imaging to estimate the sensitivity of detected signal to the change in absorption of tissue resulting from brain activation and the volume of tissue interrogated for a specific source-detector spacing. In this study, light propagation in adult head models is predicted by Monte Carlo simulation in order to investigate the effect of the thickness of the superficial tissues on the partial optical path length in the brain and on the spatial sensitivity profile. The effect of thickness of skull on the partial optical path length and spatial sensitivity profile is almost the same as that of the scalp. The effect of thickness of cerebrospinal fluid layer on the partial optical path length and spatial sensitivity profile is different from that of the scalp and skull. The partial optical path length mainly depends upon the depth of inner skull surface whilst the spatial sensitivity profile is considerably affected by the thickness of the cerebrospinal fluid layer.
KW - Spatial sensitivity profile
KW - near infrared spectroscopy
KW - topographic imaging
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M3 - Conference contribution
AN - SCOPUS:85136133456
T3 - Optics InfoBase Conference Papers
SP - 160
EP - 167
BT - European Conference on Biomedical Optics, ECBO 2003
PB - Optica Publishing Group (formerly OSA)
T2 - European Conference on Biomedical Optics, ECBO 2003
Y2 - 22 June 2003
ER -