TY - JOUR
T1 - Effects of a perilymphatic fistula on the passive vibration response of the basilar membrane
AU - Koike, Takuji
AU - Sakamoto, Chiaki
AU - Sakashita, Tasuku
AU - Hayashi, Ken
AU - Kanzaki, Sho
AU - Ogawa, Kaoru
N1 - Funding Information:
This work was supported by a Grants-in-Aid for Scientific Research (C) from the Ministry of Education, Culture, Sports, Science & Technology in Japan. We thank the section editor Anthony Gummer and the anonymous reviewers for their constructive and helpful comments and suggestions.
PY - 2012/1
Y1 - 2012/1
N2 - In this study, a three-dimensional finite-element model of the passive human cochlea was created. Dynamic behavior of the basilar membrane caused by the vibration of the stapes footplate was analyzed considering a fluid-structure interaction with the cochlear fluid. Next, the effects of a perilymphatic fistula (PLF) on the vibration of the cochlea were examined by making a small hole on the wall of the cochlea model. Even if a PLF existed in the scala vestibuli, a traveling wave was generated on the basilar membrane. When a PLF existed at the basal end of the cochlea, the shape of the traveling wave envelope showed no remarkable change, but the maximum amplitude became smaller at the entire frequency range from 0.5 to 5. kHz and decreased with decreasing frequency. In contrast, when a PLF existed at the second turn of the cochlea, the traveling wave envelope showed a notch at the position of the PLF and the maximum amplitude also became smaller. This model assists in elucidating the mechanisms of hearing loss due to a PLF from the view of dynamics.
AB - In this study, a three-dimensional finite-element model of the passive human cochlea was created. Dynamic behavior of the basilar membrane caused by the vibration of the stapes footplate was analyzed considering a fluid-structure interaction with the cochlear fluid. Next, the effects of a perilymphatic fistula (PLF) on the vibration of the cochlea were examined by making a small hole on the wall of the cochlea model. Even if a PLF existed in the scala vestibuli, a traveling wave was generated on the basilar membrane. When a PLF existed at the basal end of the cochlea, the shape of the traveling wave envelope showed no remarkable change, but the maximum amplitude became smaller at the entire frequency range from 0.5 to 5. kHz and decreased with decreasing frequency. In contrast, when a PLF existed at the second turn of the cochlea, the traveling wave envelope showed a notch at the position of the PLF and the maximum amplitude also became smaller. This model assists in elucidating the mechanisms of hearing loss due to a PLF from the view of dynamics.
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U2 - 10.1016/j.heares.2011.10.006
DO - 10.1016/j.heares.2011.10.006
M3 - Article
C2 - 22115725
AN - SCOPUS:84856608073
SN - 0378-5955
VL - 283
SP - 117
EP - 125
JO - Hearing Research
JF - Hearing Research
IS - 1-2
ER -