Effects of aging on 5-HT 2AR binding: A HRRT PET study with and without partial volume corrections

Hiroyuki Uchida, Tiffany W. Chow, David C. Mamo, Shitij Kapur, Benoit H. Mulsant, Sylvain Houle, Bruce G. Pollock, Ariel Graff-Guerrero

Research output: Contribution to journalArticlepeer-review

21 Citations (Scopus)


Objective We explored whether prior findings of reduction in serotonin 2A receptor (5-HT 2AR) binding with age could be replicated and whether high resolution research tomography (HRRT) for positron emission tomography could compensate for partial volume effects in the presence of age-related brain atrophy, which has been a traditional concern for radioligand PET studies in the elderly. Methods We derived 5-HT 2AR nondisplaceable binding potentials (BP ND) in frontal, temporal, anterior-cingulate, insula, caudate and putamen volumes of interest (VOIs) for 28 healthy subjects (mean ± SD age = 43.9 ± 17.0 years, range: 19-78 years) using HRRT. Partial volume correction (PVC) was performed in the VOI analysis. Results The 5-HT 2AR BP NDs decreased with age, a relationship best described by an exponential-decay regression. The BP NDs were found to be consistent before and after PVC, with an intra-class correlation coefficient of 0.84 and 95% confidence interval = 0.78-0.88. Conclusions These new findings update current knowledge, in that the aging process is not always uniform across the life span and suggest that PVC may not be necessary with HRRT in healthy subjects.

Original languageEnglish
Pages (from-to)1300-1308
Number of pages9
JournalInternational Journal of Geriatric Psychiatry
Issue number12
Publication statusPublished - 2011 Dec


  • HRRT
  • PET
  • PVC
  • PVE
  • [ F]setoperone
  • aging
  • receptor
  • serotonin

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Psychiatry and Mental health


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