Effects of alcohol and oxidative stress on liver pathology: The role of the mitochondrion

Alan Cahill, Carol C. Cunningham, Masayuki Adachi, Hiromasa Ishii, Shannon M. Bailey, Bernard Fromenty, Adrian Davies

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118 Citations (Scopus)


This article represents the proceedings of a symposium at the 2001 Research Society on Alcoholism meeting in Montreal, Canada. The chairs were Alan Cahill and Carol C. Cunningham. The presentations were (1) Mitochondrial regulation of ethanol-induced hepatocyte apoptosis: possible involvement of proapoptotic Bcl-2 family protein Bax, by Masayuki Adachi and Hiromasa Ishii; (2) Effects of ethanol on mitochondrial reactive oxygen species production and oxidative protein modification, by Shannon M. Bailey; (3) Acute ethanol binges elicit widespread oxidative mitochondrial DNA damage and depletion: protective effects of antioxidants and inhibitors of ethanol metabolism, by Bernard Fromenty; and (4) Effects of chronic ethanol consumption upon hepatic mtDNA oxidative modification and depletion, by Alan Cahill and Adrian Davies.

Original languageEnglish
Pages (from-to)907-915
Number of pages9
JournalAlcoholism: Clinical and Experimental Research
Issue number6
Publication statusPublished - 2002


  • Apoptosis
  • Ethanol
  • Mitochondria
  • Mitochondrial DNA
  • Oxidative stress

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Toxicology
  • Psychiatry and Mental health


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