Abstract
To investigate the effects of carteolol hydrochloride on choroidal neovascularization (CNV). Laser photocoagulation was performed to induce CNV in C 57 BL/6 mice. The response of CNV was assessed by fluorescein isothiocyanate-isolectin B 4 staining. The expression of intercellular adhesion molecule (ICAM)-1 and monocyte chemotactic protein (MCP)-1 in the retinal pigment epithelium (RPE)-choroid complex and tumor necrosis factor (TNF)-alpha in the RAW 264.7 macrophage culture was evaluated by enzyme-linked immunosorbent assay. Carteolol hydrochloride application led to significant suppression of the generation of CNV, the production of ICAM-1 and MCP-1 in the RPE-choroid, and macrophage expression of TNF-alpha. Carteolol hydrochloride prevented CNV development through its anti-inflammatory action.
| Original language | English |
|---|---|
| Pages (from-to) | 355-361 |
| Number of pages | 7 |
| Journal | Nippon Ganka Gakkai zasshi |
| Volume | 115 |
| Issue number | 4 |
| Publication status | Published - 2011 Apr |
ASJC Scopus subject areas
- General Medicine