Effects of Long-Chain Fatty Acids and Fatty Alcohols on the Growth of Streptococcus mutans

Masao Hattori, Kumi Miyachi, Sumitra Hada, Nobuko Kakiuchi, Tsuneo Namba, Fumiyuki Kiuchi, Yoshisuke Tsuda

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22 Citations (Scopus)


Minimal inhibitory concentrations (MICs) of a series of fatty acids and fatty alcohols against a cariogenic bacterium, Streptococcus mutans, were determined by a tube dilution technique. Among saturated fatty alcohols, tetradecanol and pentadecanol had the highest activity (MIC, 1.56μg/ml), while among monounsaturated fatty alcohols, 10Z-pentadecenol had the strongest activity (MIC, 0.78μg/ml). Saturated fatty acids showed relatively weak activity; tridecanoic acid had the highest activity among them (MIC, 12.5μg/ml). Among unsaturated fatty acids, 10Z-heptadecenoic 6Z-octadecenoic, 11Z-octadecenoic and 9Z,12Z-octadecadienoic acids had potent activity (MIC, 3.13 μg/ml). The antibacterial activities of methyl-branched and hydroxyl fatty acids as well as long chain dicarboxylic acids were also investigated.

Original languageEnglish
Pages (from-to)3507-3510
Number of pages4
JournalChemical and Pharmaceutical Bulletin
Issue number8
Publication statusPublished - 1987
Externally publishedYes


  • Streptococcus mutans
  • antibacterial action
  • dental caries
  • fatty acid
  • fatty alcohol
  • plaque control

ASJC Scopus subject areas

  • General Chemistry
  • Drug Discovery


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