Effects of magnesium sulfate on neuromuscular function and spontaneous breathing during sevoflurane and spinal anesthesia

Ryohei Serita, Hiroshi Morisaki, Chikako Tanaka, Shizuko Kosugi, Shigeki Sakuraba, Junzo Takeda

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)


The purpose of the present study was to determine the effects of magnesium sulfate (MgSO4) on the neuromuscular function and spontaneous breathing of patients under sevoflurane and spinal anesthesia. Twenty-two patients with a history of arrhythmia undergoing elective knee surgery were randomly assigned to two groups: group M (n = 11), administered with MgSO4 40 mg·kg-1, and group S (n = 11), administered with saline. A combination of spinal anesthesia with 2% sevoflurane inhalation was applied to all patients under spontaneous breathing. Tidal volume (Vt), respiratory rate (RR) and end-tidal carbon dioxide (ETCO2) were measured before the MgSO4 or saline injection and measurements were repeated at 5, 15, 30, and 45 min after the injection. Neuromuscular function was continuously monitored with an acceleromyograph to record the acceleration of the adductor pollicis by stimulating the ulnar nerve at a frequency of 0.1 Hz. The Vt, RR, and ETCO2 showed little change in either group, and there was no significant difference between, the groups. The single-twitch response showed significant differences between the two groups (P = 0.0006). The present study indicated that the MgSO4 had a minimal effect on spontaneous breathing in patients undergoing sevoflurane and spinal anaesthesia, but that it attenuated the safety margin of neuromuscular function.

Original languageEnglish
Pages (from-to)86-89
Number of pages4
JournalJournal of Anesthesia
Issue number1
Publication statusPublished - 2007 Feb 1


  • Magnesium sulfate
  • Neuromuscular function
  • Respiratory function
  • Sevoflurane

ASJC Scopus subject areas

  • Anesthesiology and Pain Medicine


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