Effects of neuropeptide Y on cochlear blood flow in guinea pigs

M. Itou; K. Ogawa; Y. Inoue; M. Sato; J. Kanzaki

doi:10.1080/000164801316878845

Effects of neuropeptide Y on cochlear blood flow in guinea pigs

M. Itou, K. Ogawa, Y. Inoue, M. Sato, J. Kanzaki

Department of Otorhinolaryngology

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

The aim of this study was to clarify the effects of neuropeptide Y (NPY) on cochlear blood flow (CBF) in pigmented guinea pigs. NPY was administered with or without noradrenaline (NA) by systemic perfusion or perilymphatic local perfusion, and CBF was measured using a laser Doppler flowmeter. The systemic and perilymphatic administrations of NPY with NA induced greater prolongation of the increase in and recovery of CBF than the administration of NA or NPY alone. Continuous reduction in CBF induced by NPY may play an important role in the pathogenesis of stress-induced sensorineural hearing losses, such as sudden deafness.

Original language	English
Pages (from-to)	573-578
Number of pages	6
Journal	Acta Oto-Laryngologica
Volume	121
Issue number	5
DOIs	https://doi.org/10.1080/000164801316878845
Publication status	Published - 2001

Keywords

Cochlear blood flow
Noradrenaline
Perilymphatic perfusion
Stress

ASJC Scopus subject areas

Otorhinolaryngology

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10.1080/000164801316878845

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AU - Itou, M.

AU - Ogawa, K.

AU - Inoue, Y.

AU - Sato, M.

AU - Kanzaki, J.

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AB - The aim of this study was to clarify the effects of neuropeptide Y (NPY) on cochlear blood flow (CBF) in pigmented guinea pigs. NPY was administered with or without noradrenaline (NA) by systemic perfusion or perilymphatic local perfusion, and CBF was measured using a laser Doppler flowmeter. The systemic and perilymphatic administrations of NPY with NA induced greater prolongation of the increase in and recovery of CBF than the administration of NA or NPY alone. Continuous reduction in CBF induced by NPY may play an important role in the pathogenesis of stress-induced sensorineural hearing losses, such as sudden deafness.

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KW - Noradrenaline

KW - Perilymphatic perfusion

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Effects of neuropeptide Y on cochlear blood flow in guinea pigs

Abstract

Keywords

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