Efficacy and safety of sulbactum/cefoperazone for hepato-biliary infections

Nagao Shinagawa, Shozo Takeda, Sei Ichi Oohira, Yoshikazu Yasuda, Masato Fujisaki, Hidetsugu Saito, Masakazu Ueda, Keiji Mitamura, Takeki Nishio, Masaru Itakura, Masaru Koyama, Masanori Hirano, Rempei Ohyama, Makoto Kako, Yoshihisa Amako, Koichi Okuda, Takehiko Iwasa, Atsushi Sugiyama, Makoto Hirano, Shigeki TakashimaNakaaki Ohsawa, Seishi Nakaya, Minoru Yamada, Fujio Zeze, Shinnosuke Tanaka, Kohta Yatsuka, Jun Ishii

Research output: Contribution to journalArticlepeer-review


We studied efficacy and safety of sulbactam/cefoperazone (SBT/CPT) in the treatment of biliary tract infections in hospitalized patients at 26 hospitals from February 1993 to March 1995. Secondary to dropout, 273 out of 338 patients entered in the study were evaluated, 127 patients with cholecystitis, 132 patients with cholangitis, and 14 patients with liver abscesses. Of these, 93 patients (34.1%) had malignancy as an underlying disease. SDT/CPZ had an efficacy of 79.9% (218 patients; excellent: 52, good: 166), with the efficacy in patients with cholecystitis, cholangitis and liver abscess at 89.0% (113 patients), 77.3% (102 patients) and 21.4% (3 patients), respectively. A significant difference (p<0.05) was observed in the efficacy rates of patients with (59 patients [63.4%]) and without malignancy (159 patients [88.3%]). A total of 84 strains were isolated from bile specimens of 53 patients, and the major isolates were Escherichia coli, Pseudomonas aeruginosa and Enterococcus spp. Two or more bacterial strains were isolated simulateously in 20 patients. Mild or moderate side effects (allergic reaction including rash etc.) were noted in 4 patients (1.18%), and laboratory abnormalities (increased GOT, etc.) were in 16 patients (4.71%) out of the total 338 patients. This study clearly demonstrated that SBT/CPZ retains its excellent clinical efficacy and safety profile, throughout its use over the past decade.

Original languageEnglish
Pages (from-to)13-16
Number of pages4
JournalJapanese Journal of Antibiotics
Issue number11
Publication statusPublished - 1997
Externally publishedYes

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)
  • Infectious Diseases


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