Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease

Takaaki Kawaguchi; Masayuki Fukata; Teppei Omori; Hiroki Kiyohara; Shinya Sugimoto; Kosaku Nanki; Tomohisa Sujino; Yohei Mikami; Takanori Kanai

doi:10.1093/crocol/otac017

Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease

Takaaki Kawaguchi, Masayuki Fukata, Teppei Omori, Hiroki Kiyohara, Shinya Sugimoto, Kosaku Nanki, Tomohisa Sujino, Yohei Mikami, Takanori Kanai

Research output: Contribution to journal › Article › peer-review

Abstract

Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored. Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. Conclusions: CNIs may be promising treatment options for refractory intestinal BD.

Original language	English
Article number	otac017
Journal	Crohn's and Colitis 360
Volume	4
Issue number	3
DOIs	https://doi.org/10.1093/crocol/otac017
Publication status	Published - 2022 Jul 1

Keywords

Calcineurin inhibitor
Cyclosporin
Intestinal Behçet's disease
Tacrolimus

ASJC Scopus subject areas

Gastroenterology

Access to Document

10.1093/crocol/otac017

Cite this

@article{285797c423204fb49778f61b0311a8fe,

title = "Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Beh{\c c}et's Disease",

abstract = "Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Beh{\c c}et's disease (intestinal BD) has not been explored. Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. Conclusions: CNIs may be promising treatment options for refractory intestinal BD.",

keywords = "Calcineurin inhibitor, Cyclosporin, Intestinal Beh{\c c}et's disease, Tacrolimus",

author = "Takaaki Kawaguchi and Masayuki Fukata and Teppei Omori and Hiroki Kiyohara and Shinya Sugimoto and Kosaku Nanki and Tomohisa Sujino and Yohei Mikami and Takanori Kanai",

note = "Publisher Copyright: {\textcopyright} 2022 The Author(s). Published by Oxford University Press on behalf of Crohn's & Colitis Foundation.",

year = "2022",

month = jul,

day = "1",

doi = "10.1093/crocol/otac017",

language = "English",

volume = "4",

journal = "Crohn's and Colitis 360",

issn = "2631-827X",

publisher = "Oxford University Press",

number = "3",

}

TY - JOUR

T1 - Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease

AU - Kawaguchi, Takaaki

AU - Fukata, Masayuki

AU - Omori, Teppei

AU - Kiyohara, Hiroki

AU - Sugimoto, Shinya

AU - Nanki, Kosaku

AU - Sujino, Tomohisa

AU - Mikami, Yohei

AU - Kanai, Takanori

PY - 2022/7/1

Y1 - 2022/7/1

N2 - Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored. Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. Conclusions: CNIs may be promising treatment options for refractory intestinal BD.

AB - Background: The efficacy of calcineurin inhibitors (CNIs) for induction of remission in intestinal Behçet's disease (intestinal BD) has not been explored. Methods: A multicenter retrospective case series study of patients with active intestinal BD treated with CNIs (cyclosporin and tacrolimus) was conducted. Results: Of 16 patients, 12 (75%) showed a clinical response and 5 (31.3%) achieved clinical remission after 2 weeks of CNI treatment. Similar efficacy of CNIs was observed even in 7 patients refractory to antitumor necrosis factor-alpha therapies. Endoscopic improvement was observed in 11 of 12 patients. Conclusions: CNIs may be promising treatment options for refractory intestinal BD.

KW - Calcineurin inhibitor

KW - Cyclosporin

KW - Intestinal Behçet's disease

KW - Tacrolimus

UR - http://www.scopus.com/inward/record.url?scp=85134525310&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85134525310&partnerID=8YFLogxK

U2 - 10.1093/crocol/otac017

DO - 10.1093/crocol/otac017

M3 - Article

AN - SCOPUS:85134525310

SN - 2631-827X

VL - 4

JO - Crohn's and Colitis 360

JF - Crohn's and Colitis 360

IS - 3

M1 - otac017

ER -

Efficacy of Calcineurin Inhibitors for Induction of Remission in Intestinal Behçet's Disease

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this