Efficacy of central extracorporeal life support for patients with fulminant myocarditis and cardiogenic shock

Naoki Tadokoro, Satsuki Fukushima, Kimito Minami, Takura Taguchi, Tetsuya Saito, Naonori Kawamoto, Takashi Kakuta, Osamu Seguchi, Takuya Watanabe, Seiko Nakajima Doi, Kensuke Kuroda, Keisuke Suzuki, Masanobu Yanase, Yasuhide Asaumi, Hideyuki Shimizu, Norihide Fukushima, Tomoyuki Fujita

Research output: Contribution to journalArticlepeer-review

10 Citations (Scopus)


OBJECTIVES: Fulminant myocarditis with cardiogenic shock requires extracorporeal life support (ECLS) and has poor outcomes. To improve outcomes, we have converted patients with severely impaired cardiac and multiorgan function from peripheral to central ECLS. In this study, we reviewed these patients' clinical outcomes and investigated associated factors. METHODS: We retrospectively studied 70 consecutive patients with fulminant myocarditis under peripheral support from 2006 to 2020. Forty-eight patients underwent surgical conversion to central support, and the remaining patients continued peripheral support. The end point was survival and ventricular assist device-free survival. RESULTS: More severe pulmonary congestion and multiorgan failure were present in patients with central than peripheral support. Weaning from ECLS was achieved in 95% and 62% of patients with peripheral and central support, respectively. Five-year survival was not significantly different between patients with central and peripheral support (71.2% vs 87.5%, respectively; P = 0.15). However, the ventricular assist device-free survival rate was significantly higher in patients with central than peripheral support (82.2% vs 52.0%, respectively; P = 0.017). A peak creatine kinase-MB level of >180 IU/l, rhythm disturbance and aortic valve closure were detrimental to functional recovery in patients with central support. CONCLUSIONS: Conversion to central ECLS is feasible and safe in patients with fulminant myocarditis. Patients with severe myocardial injury as shown by a high creatine kinase-MB level, rhythm disturbance and aortic valve closure should be converted to a durable left ventricular assist device.

Original languageEnglish
Pages (from-to)1184-1192
Number of pages9
JournalEuropean Journal of Cardio-thoracic Surgery
Issue number5
Publication statusPublished - 2021 Nov 1


  • Creatine kinase-MB
  • Extracorporeal life support
  • Fulminant myocarditis
  • Mechanical circulatory support
  • Rhythm disturbance
  • Ventricular assist device

ASJC Scopus subject areas

  • Surgery
  • Pulmonary and Respiratory Medicine
  • Cardiology and Cardiovascular Medicine


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