Efficacy of plate expression of meibum on tear function and ocular surface findings in meibomian gland disease

Naohiko Aketa, Megumi Shinzawa, Motoko Kawashima, Murat Dogru, Shosei Okamoto, Kazuo Tsubota, Jun Shimazaki

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)


Purpose:To evaluate the clinical effectiveness of expression treatment on meibomian gland disease (MGD).Methods:Seventeen right eyes of 17 patients with MGD were divided into 3 groups in this randomized prospective clinical study: no expression group: routine treatment with no expression (five patients, five eyes); digital expression group: routine treatment with digital expression (five patients, five eyes); and plate expression group: routine treatment with plate expression (seven patients, seven eyes). All groups received the same routine treatment for 1 month. Tear film break-up time (TBUT), vital staining scores, meibum expressibility, and the dry eye-related quality of life score (DEQS) questionnaire results were assessed before and 1 month after treatment.Results:There was a statistically significant difference of posttreatment TBUT among groups as determined by one-way analysis of variance (P<0.05). A post hoc test revealed that TBUT was statistically significantly higher in plate expression group compared with digital expression group. The fluorescein staining score did not show a statistically significant difference among the groups. Meibum expressibility and the DEQS scores improved in all groups.Conclusion:Plate expression when used as an adjunct to routine medical management of MGD has been found to be a comparatively effective treatment in terms of improvement of tear film stability compared with no expression or digital expression.

Original languageEnglish
Pages (from-to)19-22
Number of pages4
JournalEye and Contact Lens
Issue number1
Publication statusPublished - 2019 Jan 1


  • Digital expression
  • Fluorescein staining
  • Meibomian gland disease
  • Plate expression
  • Tear stability

ASJC Scopus subject areas

  • Ophthalmology


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