Efficacy of sucrose and povidone–iodine mixtures in peritoneal dialysis catheter exit-site care

Takashin Nakayama, Kohkichi Morimoto, Kiyotaka Uchiyama, Naoki Washida, Ei Kusahana, Eriko Yoshida Hama, Ryunosuke Mitsuno, Shun Tonomura, Norifumi Yoshimoto, Akihito Hishikawa, Aika Hagiwara, Tatsuhiko Azegami, Jun Yoshino, Toshiaki Monkawa, Tadashi Yoshida, Shintaro Yamaguchi, Kaori Hayashi

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)


Background: Exit-site infection (ESI) is a common recurring complication in patients undergoing peritoneal dialysis (PD). Sucrose and povidone–iodine (SPI) mixtures, antimicrobial ointments that promote wound healing, have been used for the treatment of ulcers and burns, but their efficacy in exit–site care is still unclear. Methods: This single-center retrospective observational study included patients who underwent PD between May 2010 and June 2022 and presented with episodes of ESI. Patients were divided into SPI and non-SPI groups and followed up from initial ESI onset until PD cessation, death, transfer to another facility, or June 2023. Results: Among the 82 patients (mean age 62, [54–72] years), 23 were treated with SPI. The median follow-up duration was 39 months (range, 14–64), with an overall ESI incidence of 0.70 episodes per patient-year. Additionally, 43.1% of second and 25.6% of third ESI were caused by the same pathogen as the first. The log-rank test demonstrated significantly better second and third ESI-free survival in the SPI group than that in the non-SPI group (p < 0.01 and p < 0.01, respectively). In a Cox regression analysis, adjusting for potential confounders, SPI use was a significant predictor of decreased second and third ESI episodes (hazard ratio [HR], 0.22; 95% confidence interval [CI], 0.10–0.52 and HR, 0.22; 95%CI, 0.07–0.73, respectively). Conclusions: Our results showed that the use of SPI may be a promising option for preventing the incidence of ESI in patients with PD. Trial registration: This study was approved by the Keio University School of Medicine Ethics Committee (approval number 20231078) on August 28, 2023. Retrospectively registered.

Original languageEnglish
Article number151
JournalBMC Nephrology
Issue number1
Publication statusPublished - 2024 Dec


  • Exit-site infections
  • Peritoneal dialysis
  • Povidone–iodine
  • Sucrose
  • Tunnel infections

ASJC Scopus subject areas

  • Nephrology


Dive into the research topics of 'Efficacy of sucrose and povidone–iodine mixtures in peritoneal dialysis catheter exit-site care'. Together they form a unique fingerprint.

Cite this