Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Tomohiro Fukuda; Makoto Naganuma; Shinya Sugimoto; Keiko Ono; Kosaku Nanki; Shinta Mizuno; Kayoko Hukuhara; Makoto Mutaguchi; Yoshihiro Nakazato; Kaoru Takabayashi; Nagamu Inoue; Haruhiko Ogata; Yasushi Iwao; Takanori Kanai

doi:10.1093/ibd/izy300

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Tomohiro Fukuda, Makoto Naganuma, Shinya Sugimoto, Keiko Ono, Kosaku Nanki, Shinta Mizuno, Kayoko Hukuhara, Makoto Mutaguchi, Yoshihiro Nakazato, Kaoru Takabayashi, Nagamu Inoue, Haruhiko Ogata, Yasushi Iwao, Takanori Kanai

Research output: Contribution to journal › Article › peer-review

22 Citations (Scopus)

Abstract

Background Mucosal healing (MH) is proposed as a therapeutic target for ulcerative colitis (UC). Recent studies have indicated that the rate of clinical relapse in patients with a Mayo endoscopic score (MES) of 1 is higher than that of patients with an MES of 0. However, no study has yet investigated whether therapeutic intervention prevents clinical relapse in patients with an MES of 1. Methods Patients with UC with an MES of 1 and partial Mayo score ≤2 were included in this study. All patients were followed from first colonoscopy (CS) until follow-up CS. Differences in the rate of clinical relapse (requiring additional treatment for UC) or endoscopic exacerbation (MES ≥2 and proximal extension) were compared between the therapeutic intervention (immediately after first CS) group and the nontherapeutic intervention group; risk factors for relapse were also assessed. Results Among 1523 patients with UC who underwent CS between 2013 and 2016, 220 patients were included in this study. The rate of clinical relapse (P = 0.005) and endoscopic exacerbation (P = 0.11) in patients with therapeutic intervention was lower than that in patients without therapeutic intervention. Multivariable analysis indicated that absence of therapeutic intervention (P = 0.001 for clinical relapse, P = 0.050 for endoscopic exacerbation) and a higher Ulcerative Colitis Endoscopic Index of Severity vascular pattern score immediately after first CS (P = 0.021 for clinical relapse, P = 0.019 for endoscopic exacerbation) were risk factors for both clinical relapse and endoscopic exacerbation. Conclusions Therapeutic intervention for patients with UC with an MES of 1 might prevent disease relapse.

Original language	English
Pages (from-to)	782-788
Number of pages	7
Journal	Inflammatory bowel diseases
Volume	25
Issue number	4
DOIs	https://doi.org/10.1093/ibd/izy300
Publication status	Published - 2019 Mar 14

Keywords

Mayo endoscopic score
treat to target
ulcerative colitis

ASJC Scopus subject areas

Immunology and Allergy
Gastroenterology

Access to Document

10.1093/ibd/izy300

Cite this

@article{3d44eb005ca2442da70ca485c4b12ba7,

title = "Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1",

abstract = "Background Mucosal healing (MH) is proposed as a therapeutic target for ulcerative colitis (UC). Recent studies have indicated that the rate of clinical relapse in patients with a Mayo endoscopic score (MES) of 1 is higher than that of patients with an MES of 0. However, no study has yet investigated whether therapeutic intervention prevents clinical relapse in patients with an MES of 1. Methods Patients with UC with an MES of 1 and partial Mayo score ≤2 were included in this study. All patients were followed from first colonoscopy (CS) until follow-up CS. Differences in the rate of clinical relapse (requiring additional treatment for UC) or endoscopic exacerbation (MES ≥2 and proximal extension) were compared between the therapeutic intervention (immediately after first CS) group and the nontherapeutic intervention group; risk factors for relapse were also assessed. Results Among 1523 patients with UC who underwent CS between 2013 and 2016, 220 patients were included in this study. The rate of clinical relapse (P = 0.005) and endoscopic exacerbation (P = 0.11) in patients with therapeutic intervention was lower than that in patients without therapeutic intervention. Multivariable analysis indicated that absence of therapeutic intervention (P = 0.001 for clinical relapse, P = 0.050 for endoscopic exacerbation) and a higher Ulcerative Colitis Endoscopic Index of Severity vascular pattern score immediately after first CS (P = 0.021 for clinical relapse, P = 0.019 for endoscopic exacerbation) were risk factors for both clinical relapse and endoscopic exacerbation. Conclusions Therapeutic intervention for patients with UC with an MES of 1 might prevent disease relapse.",

keywords = "Mayo endoscopic score, treat to target, ulcerative colitis",

author = "Tomohiro Fukuda and Makoto Naganuma and Shinya Sugimoto and Keiko Ono and Kosaku Nanki and Shinta Mizuno and Kayoko Hukuhara and Makoto Mutaguchi and Yoshihiro Nakazato and Kaoru Takabayashi and Nagamu Inoue and Haruhiko Ogata and Yasushi Iwao and Takanori Kanai",

note = "Funding Information: Received for publications July 19, 2018; Editorial Decision August 20, 2018. From the *Division of Gastroenterology and Hepatology, Department of Internal Medicine, †Center for Preventive Medicine, and ‡Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan Conflicts of interest: None of the authors has any financial conflicts that are relevant to this publication. Supported by: There are no specific funding sources for this study. Publisher Copyright: {\textcopyright} 2018 Crohn's & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.",

year = "2019",

month = mar,

day = "14",

doi = "10.1093/ibd/izy300",

language = "English",

volume = "25",

pages = "782--788",

journal = "Inflammatory bowel diseases",

issn = "1078-0998",

publisher = "John Wiley and Sons Inc.",

number = "4",

}

TY - JOUR

T1 - Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

AU - Fukuda, Tomohiro

AU - Naganuma, Makoto

AU - Sugimoto, Shinya

AU - Ono, Keiko

AU - Nanki, Kosaku

AU - Mizuno, Shinta

AU - Hukuhara, Kayoko

AU - Mutaguchi, Makoto

AU - Nakazato, Yoshihiro

AU - Takabayashi, Kaoru

AU - Inoue, Nagamu

AU - Ogata, Haruhiko

AU - Iwao, Yasushi

AU - Kanai, Takanori

N1 - Funding Information: Received for publications July 19, 2018; Editorial Decision August 20, 2018. From the *Division of Gastroenterology and Hepatology, Department of Internal Medicine, †Center for Preventive Medicine, and ‡Center for Diagnostic and Therapeutic Endoscopy, Keio University School of Medicine, Tokyo, Japan Conflicts of interest: None of the authors has any financial conflicts that are relevant to this publication. Supported by: There are no specific funding sources for this study. Publisher Copyright: © 2018 Crohn's & Colitis Foundation. Published by Oxford University Press. All rights reserved. For permissions. Copyright: Copyright 2019 Elsevier B.V., All rights reserved.

PY - 2019/3/14

Y1 - 2019/3/14

N2 - Background Mucosal healing (MH) is proposed as a therapeutic target for ulcerative colitis (UC). Recent studies have indicated that the rate of clinical relapse in patients with a Mayo endoscopic score (MES) of 1 is higher than that of patients with an MES of 0. However, no study has yet investigated whether therapeutic intervention prevents clinical relapse in patients with an MES of 1. Methods Patients with UC with an MES of 1 and partial Mayo score ≤2 were included in this study. All patients were followed from first colonoscopy (CS) until follow-up CS. Differences in the rate of clinical relapse (requiring additional treatment for UC) or endoscopic exacerbation (MES ≥2 and proximal extension) were compared between the therapeutic intervention (immediately after first CS) group and the nontherapeutic intervention group; risk factors for relapse were also assessed. Results Among 1523 patients with UC who underwent CS between 2013 and 2016, 220 patients were included in this study. The rate of clinical relapse (P = 0.005) and endoscopic exacerbation (P = 0.11) in patients with therapeutic intervention was lower than that in patients without therapeutic intervention. Multivariable analysis indicated that absence of therapeutic intervention (P = 0.001 for clinical relapse, P = 0.050 for endoscopic exacerbation) and a higher Ulcerative Colitis Endoscopic Index of Severity vascular pattern score immediately after first CS (P = 0.021 for clinical relapse, P = 0.019 for endoscopic exacerbation) were risk factors for both clinical relapse and endoscopic exacerbation. Conclusions Therapeutic intervention for patients with UC with an MES of 1 might prevent disease relapse.

AB - Background Mucosal healing (MH) is proposed as a therapeutic target for ulcerative colitis (UC). Recent studies have indicated that the rate of clinical relapse in patients with a Mayo endoscopic score (MES) of 1 is higher than that of patients with an MES of 0. However, no study has yet investigated whether therapeutic intervention prevents clinical relapse in patients with an MES of 1. Methods Patients with UC with an MES of 1 and partial Mayo score ≤2 were included in this study. All patients were followed from first colonoscopy (CS) until follow-up CS. Differences in the rate of clinical relapse (requiring additional treatment for UC) or endoscopic exacerbation (MES ≥2 and proximal extension) were compared between the therapeutic intervention (immediately after first CS) group and the nontherapeutic intervention group; risk factors for relapse were also assessed. Results Among 1523 patients with UC who underwent CS between 2013 and 2016, 220 patients were included in this study. The rate of clinical relapse (P = 0.005) and endoscopic exacerbation (P = 0.11) in patients with therapeutic intervention was lower than that in patients without therapeutic intervention. Multivariable analysis indicated that absence of therapeutic intervention (P = 0.001 for clinical relapse, P = 0.050 for endoscopic exacerbation) and a higher Ulcerative Colitis Endoscopic Index of Severity vascular pattern score immediately after first CS (P = 0.021 for clinical relapse, P = 0.019 for endoscopic exacerbation) were risk factors for both clinical relapse and endoscopic exacerbation. Conclusions Therapeutic intervention for patients with UC with an MES of 1 might prevent disease relapse.

KW - Mayo endoscopic score

KW - treat to target

KW - ulcerative colitis

UR - http://www.scopus.com/inward/record.url?scp=85062835527&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85062835527&partnerID=8YFLogxK

U2 - 10.1093/ibd/izy300

DO - 10.1093/ibd/izy300

M3 - Article

C2 - 30265308

AN - SCOPUS:85062835527

SN - 1078-0998

VL - 25

SP - 782

EP - 788

JO - Inflammatory bowel diseases

JF - Inflammatory bowel diseases

IS - 4

ER -

Efficacy of therapeutic intervention for patients with an ulcerative colitis mayo endoscopic score of 1

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this