Eiger and wengen: The drosophila orthologs of TNF/TNFR

Tatsushi Igaki, Hiroshi Kanda, Hideyuki Okano, Tian Xu, Masayuki Miura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

9 Citations (Scopus)


Drosophila provides a powerful genetic model for studying the in vivo regulation of biological processes, such as cell proliferation, cell differentiation, and cell death. In a large-scale ectopic-expression screen in Drosophila for identifying genes regulating cell death, the fly homolog of tumor necrosis factor (TNF) encoded by eiger (e da-l i ke cell death trig ger) was identified [7]. eiger was also isolated independently through a molecular approach [15]. eiger encodes a protein of 409 amino acids with a C-terminal TNF homology domain and a hydrophobic transmembrane domain. The sequence of the Eiger's TNF domain shows highest homology with human EDA-A2 (28%) and also shows significant homology with all known mammalian TNF superfamily members.

Original languageEnglish
Title of host publicationAdvances in TNF Family Research
Subtitle of host publicationProceedings of the 12th International TNF Conference, 2009
EditorsDavid Wallach, Andrew Kovalenko, Marc Feldmann
Number of pages6
Publication statusPublished - 2011 Dec 15

Publication series

NameAdvances in Experimental Medicine and Biology
ISSN (Print)0065-2598

ASJC Scopus subject areas

  • General Biochemistry,Genetics and Molecular Biology


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