Elevated levels of interleukin-8 and leukotriene B4 in pulmonary edema fluid of a patient with reexpansion pulmonary edema

Hidetoshi Nakamura; Akitoshi Ishizaka; Makoto Sawafuji; Tetsuya Urano; Seitaro Fujishima; Fumio Sakamaki; Koichi Sayama; Masafumi Kawamura; Ryoichi Kato; Koji Kikuchi; Minoru Kanazawa; Koichi Kobayashi; Takeo Kawashiro

doi:10.1164/ajrccm.149.4.8143038

Elevated levels of interleukin-8 and leukotriene B₄ in pulmonary edema fluid of a patient with reexpansion pulmonary edema

Hidetoshi Nakamura, Akitoshi Ishizaka, Makoto Sawafuji, Tetsuya Urano, Seitaro Fujishima, Fumio Sakamaki, Koichi Sayama, Masafumi Kawamura, Ryoichi Kato, Koji Kikuchi, Minoru Kanazawa, Koichi Kobayashi, Takeo Kawashiro

Center for General Medicine Education

Research output: Contribution to journal › Article › peer-review

58 Citations (Scopus)

Abstract

We experienced a case of reexpansion pulmonary edema (RPE) after surgical treatment of pneumothorax. In this case, protein leakage and polymorphonuclear leukocyte (PMN) accumulation were observed in the reexpanded lung. Interleukin-8 and leukotriene B₄ in edema fluid were increased at the onset of RPE. PMN elastase was also increased, though its peak was delayed. The plasma level of P-selectin, which mediates adhesion between PMN and endothelium, was elevated. We speculate that some of these fluid mediators may play important roles in chemotaxis and activation of PMN in the development of RPE.

Original language	English
Pages (from-to)	1037-1040
Number of pages	4
Journal	American journal of respiratory and critical care medicine
Volume	149
Issue number	4
DOIs	https://doi.org/10.1164/ajrccm.149.4.8143038
Publication status	Published - 1994 Apr

ASJC Scopus subject areas

Pulmonary and Respiratory Medicine
Critical Care and Intensive Care Medicine

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Nakamura, H., Ishizaka, A., Sawafuji, M., Urano, T., Fujishima, S., Sakamaki, F., Sayama, K., Kawamura, M., Kato, R., Kikuchi, K., Kanazawa, M., Kobayashi, K., & Kawashiro, T. (1994). Elevated levels of interleukin-8 and leukotriene B₄ in pulmonary edema fluid of a patient with reexpansion pulmonary edema. American journal of respiratory and critical care medicine, 149(4), 1037-1040. https://doi.org/10.1164/ajrccm.149.4.8143038

Nakamura, H, Ishizaka, A, Sawafuji, M, Urano, T, Fujishima, S, Sakamaki, F, Sayama, K, Kawamura, M, Kato, R, Kikuchi, K, Kanazawa, M, Kobayashi, K & Kawashiro, T 1994, 'Elevated levels of interleukin-8 and leukotriene B₄ in pulmonary edema fluid of a patient with reexpansion pulmonary edema', American journal of respiratory and critical care medicine, vol. 149, no. 4, pp. 1037-1040. https://doi.org/10.1164/ajrccm.149.4.8143038

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abstract = "We experienced a case of reexpansion pulmonary edema (RPE) after surgical treatment of pneumothorax. In this case, protein leakage and polymorphonuclear leukocyte (PMN) accumulation were observed in the reexpanded lung. Interleukin-8 and leukotriene B4 in edema fluid were increased at the onset of RPE. PMN elastase was also increased, though its peak was delayed. The plasma level of P-selectin, which mediates adhesion between PMN and endothelium, was elevated. We speculate that some of these fluid mediators may play important roles in chemotaxis and activation of PMN in the development of RPE.",

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AU - Nakamura, Hidetoshi

AU - Ishizaka, Akitoshi

AU - Sawafuji, Makoto

AU - Urano, Tetsuya

AU - Fujishima, Seitaro

AU - Sakamaki, Fumio

AU - Sayama, Koichi

AU - Kawamura, Masafumi

AU - Kato, Ryoichi

AU - Kikuchi, Koji

AU - Kanazawa, Minoru

AU - Kobayashi, Koichi

AU - Kawashiro, Takeo

PY - 1994/4

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AB - We experienced a case of reexpansion pulmonary edema (RPE) after surgical treatment of pneumothorax. In this case, protein leakage and polymorphonuclear leukocyte (PMN) accumulation were observed in the reexpanded lung. Interleukin-8 and leukotriene B4 in edema fluid were increased at the onset of RPE. PMN elastase was also increased, though its peak was delayed. The plasma level of P-selectin, which mediates adhesion between PMN and endothelium, was elevated. We speculate that some of these fluid mediators may play important roles in chemotaxis and activation of PMN in the development of RPE.

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Elevated levels of interleukin-8 and leukotriene B₄ in pulmonary edema fluid of a patient with reexpansion pulmonary edema

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