TY - JOUR
T1 - Elevated polyamines in saliva of pancreatic cancer
AU - Asai, Yasutsugu
AU - Itoi, Takao
AU - Sugimoto, Masahiro
AU - Sofuni, Atsushi
AU - Tsuchiya, Takayoshi
AU - Tanaka, Reina
AU - Tonozuka, Ryosuke
AU - Honjo, Mitsuyoshi
AU - Mukai, Shuntaro
AU - Fujita, Mitsuru
AU - Yamamoto, Kenjiro
AU - Matsunami, Yukitoshi
AU - Kurosawa, Takashi
AU - Nagakawa, Yuichi
AU - Kaneko, Miku
AU - Ota, Sana
AU - Kawachi, Shigeyuki
AU - Shimazu, Motohide
AU - Soga, Tomoyoshi
AU - Tomita, Masaru
AU - Sunamura, Makoto
N1 - Funding Information:
Acknowledgments: We thank all sample providers. This work was supported by grants from Yamagata Prefecture and Tsuruoka City. This work was supported in part by a Grant-in-Aid for Scientific Research (24592040) from the Ministry of Education, Science, Sports and Culture of Japan. The authors are also grateful to Professor Emeritus J. Patrick Barron of Tokyo Medical University for his editing of the manuscript.
Publisher Copyright:
© 2018 by the authors.
PY - 2018/2/5
Y1 - 2018/2/5
N2 - Detection of pancreatic cancer (PC) at a resectable stage is still difficult because of the lack of accurate detection tests. The development of accurate biomarkers in low or non-invasive biofluids is essential to enable frequent tests, which would help increase the opportunity of PC detection in early stages. Polyamines have been reported as possible biomarkers in urine and saliva samples in various cancers. Here, we analyzed salivary metabolites, including polyamines, using capillary electrophoresis-mass spectrometry. Salivary samples were collected from patients with PC (n = 39), those with chronic pancreatitis (CP, n = 14), and controls (C, n = 26). Polyamines, such as spermine, N1-acetylspermidine, and N1-acetylspermine, showed a significant difference between patients with PC and those with C, and the combination of four metabolites including N1-acetylspermidine showed high accuracy in discriminating PC from the other two groups. These data show the potential of saliva as a source for tests screening for PC.
AB - Detection of pancreatic cancer (PC) at a resectable stage is still difficult because of the lack of accurate detection tests. The development of accurate biomarkers in low or non-invasive biofluids is essential to enable frequent tests, which would help increase the opportunity of PC detection in early stages. Polyamines have been reported as possible biomarkers in urine and saliva samples in various cancers. Here, we analyzed salivary metabolites, including polyamines, using capillary electrophoresis-mass spectrometry. Salivary samples were collected from patients with PC (n = 39), those with chronic pancreatitis (CP, n = 14), and controls (C, n = 26). Polyamines, such as spermine, N1-acetylspermidine, and N1-acetylspermine, showed a significant difference between patients with PC and those with C, and the combination of four metabolites including N1-acetylspermidine showed high accuracy in discriminating PC from the other two groups. These data show the potential of saliva as a source for tests screening for PC.
KW - Metabolomics
KW - Pancreatic cancer
KW - Polyamines
KW - Saliva
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U2 - 10.3390/cancers10020043
DO - 10.3390/cancers10020043
M3 - Article
AN - SCOPUS:85042305008
SN - 2072-6694
VL - 10
JO - Cancers
JF - Cancers
IS - 2
M1 - 43
ER -
