Elevation of serum eosinophil cationic protein in primary biliary cirrhosis

Shingo Miyaguchi, Masaya Oda, Masaya Tamano, Kiyoshi Matsubara, Yoshiki Ishikawa, Hiroshi Kaneko, Yoshitaka Kamegaya, Toshio Morizane, Hidetsugu Saito, Masaharu Tsuchiya

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


It has recently been reported that in patients with primary biliary cirrhosis (PBC), eosinophils are not only increased in the peripheral blood, but also infiltrted in the liver portal tracts. There is general agreement that eosinophils and eosinophil cationic protein (ECP) released from eosinophils contribute to cellular damage, particularly in allergic inflammation. In the present study, ECP was measured by the radioimmunoassay in sera of patients with a variety of liver diseases including PBC. Serum ECP levels were significantly higher in patients with PBC than in those with chronic viral hepatitis, in those with liver cirrhosis, and in healthy subjects. There were no significant differences in serum ECP levels between symptomatic and asymptomatic PBC. The present study suggests that high levels of serum ECP may reflect high grades of eosinophil infiltration around the septal and interlobular bile ducts characterized by chronic non-suppurative destructive cholangitis, particularly in the early stages of PBC.

Original languageEnglish
Pages (from-to)285-288
Number of pages4
JournalInternational Hepatology Communications
Issue number5
Publication statusPublished - 1994 Sept 1
Externally publishedYes


  • Eosinophil cationic protein
  • Primary biliary cirrhosis
  • Radioimmunoassay

ASJC Scopus subject areas

  • Hepatology


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