En route to an efficient catalytic asymmetric synthesis of AS-3201

Tomoyuki Mashiko; Keiichi Hara; Daisuke Tanaka; Yuji Fujiwara; Naoya Kumagai; Masakatsu Shibasaki

doi:10.1021/ja0752585

En route to an efficient catalytic asymmetric synthesis of AS-3201

Tomoyuki Mashiko, Keiichi Hara, Daisuke Tanaka, Yuji Fujiwara, Naoya Kumagai, Masakatsu Shibasaki

Research output: Contribution to journal › Article › peer-review

116 Citations (Scopus)

Abstract

A catalytic asymmetric synthesis of AS-3201 via catalytic asymmetric amination with a novel lanthanum-amide complex is described. The amination reaction proceeded efficiently with as little as 1 mol % of catalyst loading, allowing for an efficient access to the key intermediate for the synthesis of AS-3201, a potent aldose reductase inhibitor.

Original language	English
Pages (from-to)	11342-11343
Number of pages	2
Journal	Journal of the American Chemical Society
Volume	129
Issue number	37
DOIs	https://doi.org/10.1021/ja0752585
Publication status	Published - 2007 Sept 19
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Chemistry(all)
Biochemistry
Colloid and Surface Chemistry

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10.1021/ja0752585

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abstract = "A catalytic asymmetric synthesis of AS-3201 via catalytic asymmetric amination with a novel lanthanum-amide complex is described. The amination reaction proceeded efficiently with as little as 1 mol % of catalyst loading, allowing for an efficient access to the key intermediate for the synthesis of AS-3201, a potent aldose reductase inhibitor.",

author = "Tomoyuki Mashiko and Keiichi Hara and Daisuke Tanaka and Yuji Fujiwara and Naoya Kumagai and Masakatsu Shibasaki",

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AU - Mashiko, Tomoyuki

AU - Hara, Keiichi

AU - Tanaka, Daisuke

AU - Fujiwara, Yuji

AU - Kumagai, Naoya

AU - Shibasaki, Masakatsu

PY - 2007/9/19

Y1 - 2007/9/19

N2 - A catalytic asymmetric synthesis of AS-3201 via catalytic asymmetric amination with a novel lanthanum-amide complex is described. The amination reaction proceeded efficiently with as little as 1 mol % of catalyst loading, allowing for an efficient access to the key intermediate for the synthesis of AS-3201, a potent aldose reductase inhibitor.

AB - A catalytic asymmetric synthesis of AS-3201 via catalytic asymmetric amination with a novel lanthanum-amide complex is described. The amination reaction proceeded efficiently with as little as 1 mol % of catalyst loading, allowing for an efficient access to the key intermediate for the synthesis of AS-3201, a potent aldose reductase inhibitor.

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En route to an efficient catalytic asymmetric synthesis of AS-3201

Abstract

ASJC Scopus subject areas

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