Enantioselective Organocatalytic Construction of Spirochroman Derivatives

Keisuke Yoshida, Hiroki Inoue, Yurika Oji, Hina Suzuki, Ken Ichi Takao

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)


Highly enantioselective organocatalytic construction of spirochromans containing a tetrasubstituted stereocenter was developed. Intramolecular oxy-Michael addition was catalyzed with a bifunctional cinchona alkaloid thiourea catalyst. A variety of spirochroman compounds containing a tetrasubstituted stereocenter were obtained with excellent enantioselectivities of up to 99% enantiomeric excess. The reaction was applied to the asymmetric formal synthesis of (-)-(R)-cordiachromene.

Original languageEnglish
Pages (from-to)10189-10197
Number of pages9
JournalJournal of Organic Chemistry
Issue number15
Publication statusPublished - 2020 Aug 7

ASJC Scopus subject areas

  • Organic Chemistry


Dive into the research topics of 'Enantioselective Organocatalytic Construction of Spirochroman Derivatives'. Together they form a unique fingerprint.

Cite this